ArticleEnvironmental research2018
A cross-sectional study of general cognitive abilities among Uruguayan school children with low-level arsenic exposure, potential effect modification by methylation capacity and dietary folate.
Article in Environmental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Provision of folic acid for reducing arsenic toxicity in arsenic-exposed children and adults.The Cochrane database of systematic reviews · 2021Pooled it
- Association of Blood Arsenic Concentrations with Lipid Markers in Uruguayan Adolescents: Exploring Effect Modification by Body Mass Index and Sex.Exposure and health · 2026Article
- Low-level arsenic exposure, childhood neighborhood disadvantage, and executive functions in adolescents from Montevideo, Uruguay.Environmental research · 2025Article
- Review
- The relationship between lead levels and reading acquisition in Spanish speakers, evidence from Uruguayan schoolers.Neurotoxicology · 2024Article
- Article
- Blood lead levels and math learning in first year of school: An association for concern.Environmental research · 2024Article
- Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024Article
- Pyrethroid and Chlorpyrifos Pesticide Exposure, General Intellectual Abilities, and Executive Functions of School Children from Montevideo, Uruguay.International journal of environmental research and public health · 2023Article
- Maternal Folate Status and the Relation between Gestational Arsenic Exposure and Child Health Outcomes.International journal of environmental research and public health · 2022Article
- Associations of maternal urinary arsenic concentrations during pregnancy with childhood cognitive abilities: The HOME study.International journal of hygiene and environmental health · 2022Article
- Contribution of household drinking water intake to arsenic and lead exposure among Uruguayan schoolchildren.Chemosphere · 2022Article
- Influence of Dietary Compounds on Arsenic Metabolism and Toxicity. Part II-Human Studies.Toxics · 2021Review
- A mixed methods study examining neighborhood disadvantage and childhood behavior problems in Montevideo, Uruguay.International journal of hygiene and environmental health · 2021Article
- Relationships among Inorganic Arsenic, Nutritional Status CpG Methylation and microRNAs: A Review of the Literature.Epigenetics insights · 2021Review
- Associations of metals and neurodevelopment: a review of recent evidence on susceptibility factors.Current epidemiology reports · 2020Article
- Associations of dietary intakes and serum levels of folate and vitamin B-12 with methylation of inorganic arsenic in Uruguayan children: Comparison of findings and implications for future research.Environmental research · 2020Article
- Executive functions in school children from Montevideo, Uruguay and their associations with concurrent low-level arsenic exposure.Environment international · 2020Article
- Vitamin B-6 Intake Is Modestly Associated with Arsenic Methylation in Uruguayan Children with Low-Level Arsenic Exposure.The Journal of nutrition · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundFew studies have evaluated the association between low-level arsenic (As) exposure and cognitive performance among children.
objectivesIn this cross-sectional study, we assessed the association between low-level As exposure and cognitive performance among 5-8 year-old children in Montevideo, and tested effect modification by As methylation capacity and children's dietary folate intake.
methodsWe measured total urinary As (UAs) concentrations and the proportion of monomethylarsonic acid (MMA) in the urine of 328 children. Seven subtests of the standardized Woodcock-Muñoz cognitive battery were used to assess cognitive performance, from which, the general intellectual abilities (GIA) score was derived. Total folate intake was estimated from two 24-h dietary recalls. Linear regression analyses were performed. Effect modification was assessed by stratifying at the median %MMA value and tertiles of total folate intake calculated as micrograms (µg) of dietary folate equivalents (dfe).
resultsThe median UAs was 11.9 µg/l (range = 1.4-93.9), mean folate intake was 337.4 (SD = 123.3) µg dfe, and median %MMA was 9.42 (range = 2.6-24.8). There was no association between UAs and cognitive abilities, and no consistent effect modification by %MMA. UAs was associated inversely with concept formation, and positively with cognitive efficiency and numbers reversed subtest in the lowest folate intake tertile; UAs was also positively associated with sound integration in the second tertile and concept formation in the highest tertile of folate intake. There was no consistent pattern of effect modification by %MMA or folate intake.
conclusionThere was no association between low-level As exposure and general cognitive abilities.
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