Evidence map›Paper›PMID 29486303›Full record

ArticleEuropean journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V2018

Effect of storage temperature on the stability of spray dried bacteriophage powders.

Sharon S Y Leung, Thaigarajan Parumasivam, An Nguyen, Thomas Gengenbach, Elizabeth A Carter, Nicholas B Carrigy, Hui Wang, Reinhard Vehring, Warren H Finlay, Sandra Morales and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 77 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Broad host range phages target globalMicrobiology spectrum · 2024
    Article
  6. Bacteriophage Production in Compliance with Regulatory Requirements.Methods in molecular biology (Clifton, N.J.) · 2024
    Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Prospects of Inhaled Phage Therapy for Combatting Pulmonary Infections.Frontiers in cellular and infection microbiology · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 4 countries.

Sharon S Y LeungFaculty of Pharmacy, University of Sydney, Sydney, NSW, Australia.
Thaigarajan ParumasivamFaculty of Pharmacy, University of Sydney, Sydney, NSW, Australia; School of Pharmaceutical Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia.
An NguyenFaculty of Pharmacy, University of Sydney, Sydney, NSW, Australia.
Thomas GengenbachCSIRO Manufacturing, Bayview Avenue, Clayton, Melbourne, Victoria, Australia.
Elizabeth A CarterVibrational Spectroscopy Core Facility & The School of Chemistry, University of Sydney, Sydney, NSW, Australia.
Nicholas B CarrigyDepartment of Mechanical Engineering, University of Alberta, Edmonton, Alberta, Canada.
Hui WangDepartment of Mechanical Engineering, University of Alberta, Edmonton, Alberta, Canada.
Reinhard VehringDepartment of Mechanical Engineering, University of Alberta, Edmonton, Alberta, Canada.
Warren H FinlayDepartment of Mechanical Engineering, University of Alberta, Edmonton, Alberta, Canada.
Sandra MoralesAmpliPhi Biosciences AU, 7/27 Dale Street, Brookvale, Sydney, NSW, Australia.
Warwick J BrittonTuberculosis Research Program, Centenary Institute, and Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
Elizabeth KutterThe Evergreen State College, Olympia, WA, USA.
Hak-Kim ChanFaculty of Pharmacy, University of Sydney, Sydney, NSW, Australia. Electronic address: kim.chan@sydney.edu.au.
The University of Sydney · AUUniversity of Alberta · CACSIRO Manufacturing · AUThe Evergreen State College · US

Funding

Harnessing bacteriophages as natural predators to combat the superbugs: a pulmonary drug delivery approachR33AI121627 · NIAID · UNIVERSITY OF SYDNEY · PI CHAN, KIM · 2018 to 2020
$598k
Harnessing bacteriophages as natural predators to combat the superbugs: a pulmonary drug delivery approachR21AI121627 · NIAID · UNIVERSITY OF SYDNEY · PI CHAN, KIM · 2016 to 2017
$287k
NIAID NIH HHS R21 AI121627NIAID NIH HHS R33 AI121627
6 · The paper itself

Abstract

This study aimed to assess the robustness of using a spray drying approach and formulation design in producing inhalable phage powders. Two types of Pseudomonas phages, PEV2 (Podovirus) and PEV40 (Myovirus) in two formulations containing different amounts of trehalose (70% and 60%) and leucine (30% and 40%) were studied. Most of the surface of the produced powders was found to be covered in crystalline leucine. The powders were stored at 4 °C and 20 °C under vacuum. The phage stability and in vitro aerosol performance of the phage powders were examined on the day of production and after 1, 3 and 12 months of storage. A minor titer loss during production was observed for both phages (0.2-0.8 log

Indexed as

Administration, InhalationAerosolsBacteriophagesChemistry, PharmaceuticalDesiccationDrug StabilityDry Powder InhalersExcipientsLungParticle SizePowdersTemperatureTrehaloseAerosolsExcipientsPowdersTrehaloseAntibiotic resistancePEV2PEV40PhagePhage dry powderPulmonary infections

Identifiers

PMID29486303
PMCPMC5948144
OpenAlexW2794284081

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.