ArticleNeurobiology of disease2018
Phase-amplitude coupling and epileptogenesis in an animal model of mesial temporal lobe epilepsy.
Article in Neurobiology of disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 52 citations in OpenAlex.
- Effects of pharmacological modulation of cortical excitability on resting-state EEG PAC in humans.Scientific reports · 2026Article
- Flexible Deep-Brain Probe for High-Fidelity Multi-Scale Recording of Epileptic Network Dynamics.Micromachines · 2025Article
- Dynamic evolution of frontal-temporal network connectivity in temporal lobe epilepsy: A magnetoencephalography study.Human brain mapping · 2024Article
- Phase-Amplitude Coupling Localizes Pathologic Brain with Aid of Behavioral Staging in Sleep.Life (Basel, Switzerland) · 2023Article
- Article
- Cross-Frequency Brain Network Dynamics Support Pitch Change Detection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Cortical Cross-Frequency Coupling Is Affected byFrontiers in neuroscience · 2022Article
- Altered neocortical oscillations and cellular excitability in an in vitro Wwox knockout mouse model of epileptic encephalopathy.Neurobiology of disease · 2021Article
- Article
- Multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody-mediated encephalitis.Communications biology · 2021Article
- Oscillatory Entrainment of the Frequency-following Response in Auditory Cortical and Subcortical Structures.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Addressing Pitfalls in Phase-Amplitude Coupling Analysis with an Extended Modulation Index Toolbox.Neuroinformatics · 2021Article
- Amygdala Low-Frequency Stimulation Reduces Pathological Phase-Amplitude Coupling in the Pilocarpine Model of Epilepsy.Brain sciences · 2020Article
- The value of intra-operative electrographic biomarkers for tailoring during epilepsy surgery: from group-level to patient-level analysis.Scientific reports · 2020Article
- Rodent EEG: Expanding the Spectrum of Analysis.Epilepsy currents · 2020Article
- Variation of functional brain connectivity in epileptic seizures: an EEG analysis with cross-frequency phase synchronization.Cognitive neurodynamics · 2020Article
- Association Between Interictal High-Frequency Oscillations and Slow Wave in Refractory Focal Epilepsy With Good Surgical Outcome.Frontiers in human neuroscience · 2020Article
- Differentially Altered NMDAR Dependent and Independent Long-Term Potentiation in the CA3 Subfield in a Model of Anti-NMDAR Encephalitis.Frontiers in synaptic neuroscience · 2018Article
- More Is More: Potential Benefits of Characterizing High-Frequency Activity Over Long Durations.Epilepsy currentsArticle
- High-Frequency Activity During Stereotyped Low-Frequency Events Might Help to Identify the Seizure Onset Zone.Epilepsy currentsArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Polyrhythmic coupling of oscillatory components in electrophysiological signals results from the interactions between neuronal sub-populations within and between cell assemblies. Since the mechanisms underlying epileptic disorders should affect such interactions, abnormal level of cross-frequency coupling is expected to provide a signal marker of epileptogenesis. We measured phase-amplitude coupling (PAC), a form of cross-frequency coupling between neural oscillations, in a rodent model of mesial temporal lobe epilepsy. Sprague-Dawley rats (n = 4, 250-300 g) were injected with pilocarpine (380 mg/kg, i.p) to induce a status epilepticus (SE) that was stopped after 1 h with diazepam (5 mg/kg, s.c.) and ketamine (50 mg/kg, s.c.). Control animals (n = 6) did not receive any injection or treatment. Three days after SE, all animals were implanted with bipolar electrodes in the hippocampal CA3 subfield, entorhinal cortex, dentate gyrus and subiculum. Continuous video/EEG recordings were performed 24/7 at a sampling rate of 2 kHz, over 15 consecutive days. Pilocarpine-treated animals showed interictal spikes (5.25 (±2.5) per minute) and seizures (n = 32) that appeared 7 (±0.8) days after SE. We found that CA3 was the seizure onset zone in most epileptic animals, with stronger ongoing PAC coupling between seizures than in controls (Kruskal-Wallis test: chi
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