Evidence map›Paper›PMID 29486140›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2018

Severe hypoglycemia-induced sudden death is mediated by both cardiac arrhythmias and seizures.

Candace M Reno, Allie Skinner, Justin Bayles, Y Stefanie Chen, Dorit Daphna-Iken, Simon J Fisher

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Acta biochimica et biophysica Sinica · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Candace M RenoDivision of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, University of Utah , Salt Lake City, Utah.ORCID 0000-0001-8272-1212
Allie SkinnerDivision of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, University of Utah , Salt Lake City, Utah.
Justin BaylesDivision of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, University of Utah , Salt Lake City, Utah.
Y Stefanie ChenDivision of Endocrinology, Metabolism, and Lipid Research, Department of Medicine, Washington University , St. Louis, Missouri.
Dorit Daphna-IkenDivision of Endocrinology, Metabolism, and Lipid Research, Department of Medicine, Washington University , St. Louis, Missouri.
Simon J FisherDivision of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, University of Utah , Salt Lake City, Utah.
University of Utah · USWashington University in St. Louis · US

Funding

Interdisciplinary Training Program in MetabolismT32DK091317 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI SCOTT A SUMMERS · 2011 to 2026
$4.8M
DIABETES ASSOCIATED BRAIN DAMAGE FOLLOWING SEVERE HYPOGLYCEMIAR01NS070235 · NINDS · WASHINGTON UNIVERSITY · PI FISHER, SIMON J · 2010 to 2014
$1.5M
NIDDK NIH HHS T32 DK091317NINDS NIH HHS R01 NS070235
6 · The paper itself

Abstract

We previously demonstrated that insulin-induced severe hypoglycemia-associated sudden death is largely mediated by fatal cardiac arrhythmias. In the current study, a pharmacological approach was taken to explore the potential contribution of hypoglycemic seizures and the sympathoadrenergic system in mediating severe hypoglycemia-associated sudden death. Adult Sprague-Dawley rats were randomized into one of four treatment groups: 1) saline (SAL), 2) anti-arrhythmic (β

Indexed as

Adrenergic beta-1 Receptor AntagonistsAnimalsAnti-Arrhythmia AgentsAnticonvulsantsArrhythmias, CardiacAtenololDeath, Sudden, CardiacDrug Therapy, CombinationElectrocardiographyHypoglycemiaLevetiracetamMaleRatsRats, Sprague-DawleySeizuresAdrenergic beta-1 Receptor AntagonistsAnti-Arrhythmia AgentsAnticonvulsantsAtenololLevetiracetamcardiac arrhythmiasdiabeteshypoglycemiaseizuressudden death

Identifiers

PMID29486140
PMCPMC6139495
OpenAlexW2788772364

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.