Evidence map›Paper›PMID 29485903›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2018

Metabolic and molecular framework for the enhancement of endurance by intermittent food deprivation.

Krisztina Marosi, Keelin Moehl, Ignacio Navas-Enamorado, Sarah J Mitchell, Yongqing Zhang, Elin Lehrmann, Miguel A Aon, Sonia Cortassa, Kevin G Becker, Mark P Mattson

Open access · bronzeAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 60 citations in OpenAlex.

  1. Trial
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  8. Does eating less or exercising more to reduce energy availability produce distinct metabolic responses?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  9. Review
  10. Article
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  12. The impact of diet upon mitochondrial physiology (Review).International journal of molecular medicine · 2022
    Review
  13. Article
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  15. Article
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Krisztina MarosiLaboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Keelin MoehlLaboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Ignacio Navas-EnamoradoTranslational Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Sarah J MitchellDepartment of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Yongqing ZhangGene Expression and Genomics Unit Core Facility, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Elin LehrmannGene Expression and Genomics Unit Core Facility, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Miguel A AonLaboratory of Cardiovascular Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Sonia CortassaLaboratory of Cardiovascular Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Kevin G BeckerGene Expression and Genomics Unit Core Facility, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Mark P MattsonLaboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Institute on Aging · USNational Institute on Aging · USHarvard University · USJohns Hopkins University · US

Funding

Analysis of complex biological systems by microarray based gene expressionZICAG000616 · NIA · NATIONAL INSTITUTE ON AGING · PI DE, SUPRIYO · 2009 to 2025
$15.5M
6 · The paper itself

Abstract

Evolutionary considerations suggest that the body has been optimized to perform at a high level in the food-deprived state when fatty acids and their ketone metabolites are a major fuel source for muscle cells. Because controlled food deprivation in laboratory animals and intermittent energy restriction in humans is a potent physiologic stimulus for ketosis, we designed a study to determine the impact of intermittent food deprivation during endurance training on performance and to elucidate the underlying cellular and molecular mechanisms. Male mice were randomly assigned to either ad libitum feeding or alternate-day food deprivation (ADF) groups, and half of the mice in each diet group were trained daily on a treadmill for 1 mo. A run to exhaustion endurance test performed at the end of the training period revealed superior performance in the mice maintained on ADF during training compared to mice fed ad libitum during training. Maximal O

Indexed as

Food DeprivationPhysical EnduranceAnimalsMaleMiceMice, Inbred C57BLMuscle, SkeletalOrganelle BiogenesisPhysical Conditioning, Animalexerciseintermittent fastingketonemitochondrial biogenesismuscle

Identifiers

PMID29485903
PMCPMC5998977
OpenAlexW2790031846

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.