Trial reportAmerican journal of respiratory and critical care medicine2018
Association between Emphysema and Chronic Obstructive Pulmonary Disease Outcomes in the COPDGene and SPIROMICS Cohorts: A Post Hoc Analysis of Two Clinical Trials.
Registry-linked trialAbstract readClinical TrialLetter
In one paragraph
Trial report in American journal of respiratory and critical care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01969344 (Subpopulations and Intermediate Outcome Measures in COPD Study), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Subpopulations and Intermediate Outcome Measures in COPD Study
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Use of Computed Tomography Densitometry for the Assessment of Emphysema in Clinical Trials: A Position Paper from the Fleischner Society.American journal of respiratory and critical care medicine · 2025Pooled it
- Integrating network annotation from multiple correlated traits to improve polygenic risk scores based on GWAS summary statistics.Research square · 2026Article
- Imaging in Chronic Obstructive Pulmonary Disease: Ready for Prime Time?Tuberculosis and respiratory diseases · 2026Article
- Pulmonary vascular features on chest computed tomography differentially associate with adverse outcomes in smokers in COPDGene.Annals of the American Thoracic Society · 2026Article
- Bridging the Gap: Small Airways, Mechanical Stress, and the Evolution of Emphysema.American journal of respiratory and critical care medicine · 2025Article
- Article
- Centrilobular emphysema and airway dysanapsis: factors associated with low respiratory function in younger smokers.ERJ open research · 2024Article
- Correlation Between HIF1-A Expression and Airway Remodeling in COPD.International journal of chronic obstructive pulmonary disease · 2024Article
- Plasma metabolomics and quantitative interstitial abnormalities in ever-smokers.Respiratory research · 2023Article
- Article
- Association between blood eosinophil count and small airway eosinophils in smokers with and without COPD.ERJ open research · 2023Article
- Optimal Threshold of FEVAmerican journal of respiratory and critical care medicine · 2023Article
- Comparing Racial Differences in Emphysema Prevalence Among Adults With Normal Spirometry: A Secondary Data Analysis of the CARDIA Lung Study.Annals of internal medicine · 2022Observational
- Chest CT-assessed comorbidities and all-cause mortality risk in COPD patients in the BODE cohort.Respirology (Carlton, Vic.) · 2022Article
- Editorial: The heterogeneity in COPD phenotypes.Frontiers in medicine · 2022Article
- Emphysema-Predominant COPD Had a Greater 5-Year Mortality and a Worse Annual Decline in Lung Function Than Airway Obstruction-Predominant COPD or Asthma at Initial Same Degree of Airflow Obstruction.Medicina (Kaunas, Lithuania) · 2021Observational
- Article
- Effect of perioperative bronchodilator therapy on postoperative pulmonary function among lung cancer patients with COPD.Scientific reports · 2021Article
- Relationship between Emphysema Progression at CT and Mortality in Ever-Smokers: Results from the COPDGene and ECLIPSE Cohorts.Radiology · 2021Article
- Markers of disease activity in COPD: an 8-year mortality study in the ECLIPSE cohort.The European respiratory journal · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
MeiLan K Han1 University of Michigan Ann Arbor, Michigan.
Nabihah Tayob2 University of Texas MD Anderson Cancer Center Houston, Texas.
Susan Murray1 University of Michigan Ann Arbor, Michigan.
Prescott G Woodruff3 University of San Francisco San Francisco, California.
Jeffrey L Curtis1 University of Michigan Ann Arbor, Michigan.
Victor Kim5 Temple University Philadelphia, Pennsylvania.
Gerard Criner5 Temple University Philadelphia, Pennsylvania.
Craig J Galban6 University of Iowa College of Medicine Iowa City, Iowa.
Brian D Ross6 University of Iowa College of Medicine Iowa City, Iowa.
Eric A Hoffman1 University of Michigan Ann Arbor, Michigan.
David A Lynch7 National Jewish Health Denver, Colorado and.
Ella Kazerooni6 University of Iowa College of Medicine Iowa City, Iowa.
Fernando J Martinez1 University of Michigan Ann Arbor, Michigan.
COPDGene and SPIROMICS Investigators
Funding
Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9MPulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5MMetabolomic signatures of empysema and COPD progression in the COPDGene cohortR01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2012 to 2016
$31.1MSPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9MGenetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M(2 of 2) Genetic Epidemiology of COPDR01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2012 to 2016
$18.9MParametric Response Mapping in COPDR01HL122438 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAN, MEILAN K, MARTINEZ, FERNANDO J · 2014 to 2017
$4.0MDefining Pathways in COPD Patient Oriented ResearchK24HL138188 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MeiLan K Han · 2017 to 2026
$1.2MMentoring Research in Precision Medicine for Lung DiseaseK24HL137013 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2017 to 2026
$1.2MModulation of Steroid Suppression by Alveolar Macrophage EfferocytosisI01CX000911 · VA · VETERANS HEALTH ADMINISTRATION · PI CURTIS, JEFFREY LOUIS · 2016 to 2020
–CSRD VA I01 CX000911NHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS K24 HL137013NHLBI NIH HHS K24 HL138188NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL089897NHLBI NIH HHS R01 HL122438NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NHLBI NIH HHS U01 HL137880NIEHS NIH HHS P30 ES005605
Abstract
PubMed holds no abstract for this paper.
Indexed as
Early Detection of CancerAdultAgedAged, 80 and overBiomarkersCohort StudiesFemaleHumansLung NeoplasmsMaleMiddle AgedPulmonary Disease, Chronic ObstructivePulmonary EmphysemaRisk AssessmentSeverity of Illness IndexBiomarkers
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT01969344ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.