Evidence map›Paper›PMID 29485730›Full record

ReviewMedicinal research reviews2018

Biologically active quinoline and quinazoline alkaloids part II.

Xiao-Fei Shang, Susan L Morris-Natschke, Guan-Zhou Yang, Ying-Qian Liu, Xiao Guo, Xiao-Shan Xu, Masuo Goto, Jun-Cai Li, Ji-Yu Zhang, Kuo-Hsiung Lee

Abstract readReview
In one paragraph

Review in Medicinal research reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed.

  1. Article
  2. Chemistry and Biological Activity of 11Molecules (Basel, Switzerland) · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Quinazolines [Molecules (Basel, Switzerland) · 2025
    Review
  9. 4(3International journal of molecular sciences · 2025
    Review
  10. Article
  11. Medicinal chemistry (Shariqah (United Arab Emirates)) · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Comprehensive Analysis of 11 Species ofMolecules (Basel, Switzerland) · 2024
    Article
  17. Article
  18. Review
  19. Phytochemistry Profile, Antimicrobial and Antitumor Potential of the Methanolic Extract ofEvidence-based complementary and alternative medicine : eCAM · 2024
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiao-Fei ShangKey Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture, Key Laboratory of New Animal Drug Project, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, P.R. China.
Susan L Morris-NatschkeNatural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina.
Guan-Zhou YangSchool of Pharmacy, Lanzhou University, Lanzhou, P.R. China.
Ying-Qian LiuSchool of Pharmacy, Lanzhou University, Lanzhou, P.R. China.
Xiao GuoTibetan Medicine Research Center of Qinghai University, Qinghai University Tibetan Medical College, Qinghai University, Xining, P.R. China.
Xiao-Shan XuSchool of Pharmacy, Lanzhou University, Lanzhou, P.R. China.
Masuo GotoNatural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina.
Jun-Cai LiSchool of Pharmacy, Lanzhou University, Lanzhou, P.R. China.
Ji-Yu ZhangKey Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture, Key Laboratory of New Animal Drug Project, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, P.R. China.
Kuo-Hsiung LeeNatural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina.ORCID 0000-0002-6562-0070

Funding

Novel Antitumor AgentsR01CA177584 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEE, KUO-HSIUNG · 2013 to 2017
$1.9M
NCI NIH HHS R01 CA177584
6 · The paper itself

Abstract

To follow-up on our prior Part I review, this Part II review summarizes and provides updated literature on novel quinoline and quinazoline alkaloids isolated during the period of 2009-2016, together with the biological activity and the mechanisms of action of these classes of natural products. Over 200 molecules with a broad range of biological activities, including antitumor, antiparasitic and insecticidal, antibacterial and antifungal, cardioprotective, antiviral, anti-inflammatory, hepatoprotective, antioxidant, anti-asthma, antitussive, and other activities, are discussed. This survey should provide new clues or possibilities for the discovery of new and better drugs from the original naturally occurring quinoline and quinazoline alkaloids.

Indexed as

AlkaloidsAnti-Inflammatory AgentsAntioxidantsHumansProtective AgentsQuinazolinesQuinolinesAlkaloidsAnti-Inflammatory AgentsAntioxidantsProtective AgentsQuinazolinesquinolineQuinolinesbiological activitiescamptothecinnatural productsquinazoline alkaloidsquinoline alkaloids

Identifiers

PMID29485730
PMCPMC6105521

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.