Observational studyInternational journal of radiation oncology, biology, physics2018
Association Between Treatment at High-Volume Facilities and Improved Overall Survival in Soft Tissue Sarcomas.
Observational study in International journal of radiation oncology, biology, physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Preoperative hypofractionated radiotherapy for soft tissue sarcomas: a systematic review.Radiation oncology (London, England) · 2022Pooled it
- Five-Day Preoperative Radiation Therapy for Patients With High-Risk Soft Tissue Sarcoma: A Nonrandomized Clinical Trial.JAMA network open · 2025Trial
- Hypofractionated, 3-week, preoperative radiotherapy for patients with soft tissue sarcomas (HYPORT-STS): a single-centre, open-label, single-arm, phase 2 trial.The Lancet. Oncology · 2022Trial
- A Phase II Trial of 5-Day Neoadjuvant Radiotherapy for Patients with High-Risk Primary Soft Tissue Sarcoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020Trial
- [Should the surgical treatment of primary malignant bone tumors only take place in high-volume centers?]Orthopadie (Heidelberg, Germany) · 2026Review
- Review
- Twelve-Month Metastatic State as a Landmark-Based Prognostic Stratifier in Metastatic Sarcoma.Cancers · 2026Article
- The impact of non-centralised surgical treatment on local recurrence, amputation rate and survival in patients with extremity soft tissue sarcoma.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Article
- The Impact of Radiation Dose to Bowel on the Risk of Developing Gastrointestinal Toxicities When Treating Abdominopelvic Soft-Tissue Sarcomas With Preoperative Radiation Therapy.Advances in radiation oncology · 2026Article
- Article
- Distinguishing benign and malignant myxoid soft tissue tumors: Performance of radiomics vs. radiologists.PloS one · 2025Article
- Article
- Article
- Impact of Hospital Case Volume on Uterine Sarcoma Prognosis: SARCUT Study Subanalysis.Annals of surgical oncology · 2023Article
- Hospital facility characteristics and socioeconomic factors on outcomes and treatment in patients with multiple myeloma: National Cancer Database analysis.Annals of hematology · 2023Article
- Centralized and Interdisciplinary Therapy Management in the Treatment of Sarcomas.Life (Basel, Switzerland) · 2023Review
- Radiation Therapy for Retroperitoneal Sarcomas: A Strass-Ful Situation.Current oncology (Toronto, Ont.) · 2023Review
- Textbook oncologic outcomes and regionalization among patients undergoing hepatic resection for intrahepatic cholangiocarcinoma.Journal of surgical oncology · 2023Article
- Prediction tools for the personalized management of soft-tissue sarcomas of the extremity.The bone & joint journal · 2022Review
- The role of neoadjuvant radiochemotherapy in the management of localized high-grade soft tissue sarcoma.Radiation oncology (London, England) · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
purposeSoft tissue sarcomas (STS) are rare malignancies that require complex multidisciplinary management. Therefore, facilities with high sarcoma case volume may demonstrate superior outcomes. We hypothesized that STS treatment at high-volume (HV) facilities would be associated with improved overall survival (OS). METHODS AND MATERIALS: Patients aged ≥18 years with nonmetastatic STS treated with surgery and radiation therapy at a single facility from 2004 through 2013 were identified from the National Cancer Database. Facilities were dichotomized into HV and low-volume (LV) cohorts based on total case volume over the study period. OS was assessed using multivariable Cox regression with propensity score-matching. Patterns of care were assessed using multivariable logistic regression analysis.
resultsOf 9025 total patients, 1578 (17%) and 7447 (83%) were treated at HV and LV facilities, respectively. On multivariable analysis, high educational attainment, larger tumor size, higher grade, and negative surgical margins were statistically significantly associated with treatment at HV facilities; conversely, black race and non-metropolitan residence were negative predictors of treatment at HV facilities. On propensity score-matched multivariable analysis, treatment at HV facilities versus LV facilities was associated with improved OS (hazard ratio, 0.87, 95% confidence interval, 0.80-0.95; P = .001). Older age, lack of insurance, greater comorbidity, larger tumor size, higher tumor grade, and positive surgical margins were associated with statistically significantly worse OS.
conclusionsIn this observational cohort study using the National Cancer Database, receipt of surgery and radiation therapy at HV facilities was associated with improved OS in patients with STS. Potential sociodemographic disparities limit access to care at HV facilities for certain populations. Our findings highlight the importance of receipt of care at HV facilities for patients with STS and warrant further study into improving access to care at HV facilities.
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