Evidence map›Paper›PMID 29484546›Full record

Trial reportClinical oral investigations2018

A randomized triple-blind crossover trial of a hydrocolloid-containing dentifrice as a controlled-release system for fluoride.

Vanessa Feitosa Alves, Vanderlúcia Gomes Moreira, Andréia Felix Soares, Luísa Simões de Albuquerque, Helene Soares Moura, Alisson de Oliveira Silva, Fábio Correia Sampaio

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical oral investigations, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02809014 (In Vivo Evaluation of an Experimental Fluoride-containing Dentifrice With Hydrocolloid), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02809014 nacompletednot on this map

In Vivo Evaluation of an Experimental Fluoride-containing Dentifrice With Hydrocolloid

TypeinterventionalSponsorFabio Correia SampaioRan2016 to 2017Enrolled24ConditionsDental CariesArmsDentifrice F-Complex, Dentifrice F-Complex + NaF, Dentifrice standard, Dentifrice with tara gum
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vanessa Feitosa AlvesDepartment of Clinical and Social Dentistry, Federal University of Paraiba, Castelo Branco, s/n., João Pessoa, Paraiba, 58051-900, Brazil. vanessafalves@hotmail.com.ORCID http://orcid.org/0000-0002-6676-9037
Vanderlúcia Gomes MoreiraDepartment of Clinical and Social Dentistry, Federal University of Paraiba, Castelo Branco, s/n., João Pessoa, Paraiba, 58051-900, Brazil.
Andréia Felix SoaresDepartment of Clinical and Social Dentistry, Federal University of Paraiba, Castelo Branco, s/n., João Pessoa, Paraiba, 58051-900, Brazil.
Luísa Simões de AlbuquerqueDepartment of Clinical and Social Dentistry, Federal University of Paraiba, Castelo Branco, s/n., João Pessoa, Paraiba, 58051-900, Brazil.
Helene Soares MouraDepartment of Clinical and Social Dentistry, Federal University of Paraiba, Castelo Branco, s/n., João Pessoa, Paraiba, 58051-900, Brazil.
Alisson de Oliveira SilvaLauro Wanderley University Hospital, Federal University of Paraiba, Castelo Branco, s/n., João Pessoa, Paraiba, 58051-900, Brazil.
Fábio Correia SampaioDepartment of Clinical and Social Dentistry, Federal University of Paraiba, Castelo Branco, s/n., João Pessoa, Paraiba, 58051-900, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate retention of intraoral fluoride in biofilm and saliva, an experimental dentifrice containing hydrocolloid (tara gum) was used as a controlled-release system for fluoride (F). MATERIALS AND

methodsIn a triple-blind randomized crossover trial with washout, 18 individuals used the following different dentifrices for a week: 100-TGF (sodium fluoride NaF associated with tara gum, 1100 mg/L), 50-TGF (50% NaF associated with tara gum + 50% free NaF, 1100 mg/L), PC (free NaF, 1100 mg/L), TG (with tara gum and without F), and placebo (without F or tara gum). On the seventh day of dentifrice use, biofilm was collected at 1 and 12 h, and saliva was collected up to 60 min and 12 h after the last toothbrushing. F concentrations were determined by physico-chemical analysis of fluoride using the hexamethyldisiloxane-facilitated diffusion technique. Data were subjected to two-way analysis of variance (repeated measures) and Spearman's correlation coefficient (p < 0.05) testing.

resultsNo significant difference was observed with the same dentifrice regarding F retention in biofilm at 1 and 12 h after toothbrushing for the 100-TGF, placebo, and TG groups (p > 0.05). The highest area under the curve values in saliva were found for the 50-TGF, 100-TGF, and PC groups.

conclusionThe dentifrice containing hydrocolloid as a controlled-release system for F promoted F retention in the oral cavity, even at 12 h after brushing. CLINICAL RELEVANCE: Hydrocolloid added to dentifrices as a controlled-release system for F might contribute to a higher anti-caries effect.

trial registrationNCT02809014.

Indexed as

AdultBiofilmsCariostatic AgentsCross-Over StudiesDelayed-Action PreparationsDentifricesDose-Response Relationship, DrugFemaleHumansMalePlant GumsSalivaSodium FluorideToothbrushingTreatment OutcomeCariostatic AgentsDelayed-Action PreparationsDentifricesPlant GumsSodium Fluoridetara gumDentifriceFluorideNatural productTara gum

Identifiers

PMID29484546

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.