Evidence map›Paper›PMID 29484523›Full record

ArticleNeurochemical research2019

Muscarinic Receptor-Dependent Long Term Depression in the Perirhinal Cortex and Recognition Memory are Impaired in the rTg4510 Mouse Model of Tauopathy.

Sarah E Scullion, Gareth R I Barker, E Clea Warburton, Andrew D Randall, Jonathan T Brown

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurochemical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sarah E ScullionSchool of Physiology and Pharmacology and Neuroscience, Medical Sciences Building, University of Bristol, Bristol, BS8 1TD, UK.
Gareth R I BarkerSchool of Physiology and Pharmacology and Neuroscience, Medical Sciences Building, University of Bristol, Bristol, BS8 1TD, UK.
E Clea WarburtonSchool of Physiology and Pharmacology and Neuroscience, Medical Sciences Building, University of Bristol, Bristol, BS8 1TD, UK.
Andrew D RandallSchool of Physiology and Pharmacology and Neuroscience, Medical Sciences Building, University of Bristol, Bristol, BS8 1TD, UK. A.Randall@exeter.ac.uk.ORCID http://orcid.org/0000-0001-8852-3671
Jonathan T BrownSchool of Physiology and Pharmacology and Neuroscience, Medical Sciences Building, University of Bristol, Bristol, BS8 1TD, UK.
University of Bristol · GBUniversity of Exeter · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegenerative diseases affecting cognitive dysfunction, such as Alzheimer's disease and fronto-temporal dementia, are often associated impairments in the visual recognition memory system. Recent evidence suggests that synaptic plasticity, in particular long term depression (LTD), in the perirhinal cortex (PRh) is a critical cellular mechanism underlying recognition memory. In this study, we have examined novel object recognition and PRh LTD in rTg4510 mice, which transgenically overexpress tau

Indexed as

Alzheimer DiseaseAnimalsDepressionDisease Models, AnimalLong-Term Synaptic DepressionMemoryMice, TransgenicNeuronal PlasticityPerirhinal CortexReceptors, MuscarinicSynaptic TransmissionReceptors, MuscarinicAlzheimer’s diseaseFronto-temporal dementiarTg4510Synaptic plasticity

Identifiers

PMID29484523
PMCPMC6420433
OpenAlexW2794274880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.