ArticleDiabetologia2018
Prediction of clamp-derived insulin sensitivity from the oral glucose insulin sensitivity index.
Article in Diabetologia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- The association of triglyceride-glucose index with major adverse cardiovascular and cerebrovascular events after acute myocardial infarction: a meta-analysis of cohort studies.Nutrition & diabetes · 2024Pooled it
- Relationship between the triglyceride-glucose index and risk of cardiovascular diseases and mortality in the general population: a systematic review and meta-analysis.Cardiovascular diabetology · 2022Pooled it
- Changes in ectopic lipids, insulin sensitivity, and beta cell function after a low-fat vegan diet in adults with type 2 diabetes: a 16-week single-arm clinical trial.BMJ open diabetes research & care · 2026Trial
- Insulin resistance and muscle weakness are synergistic risk factors for silent lacunar infarcts: the Bunkyo Health Study.Scientific reports · 2021Trial
- Trial
- Short-term dietary reduction of branched-chain amino acids reduces meal-induced insulin secretion and modifies microbiome composition in type 2 diabetes: a randomized controlled crossover trial.The American journal of clinical nutrition · 2019Trial
- Trial
- Insulin resistance indices and periodontitis in patients with diabetes: A nationwide population-based study.Journal of periodontology · 2026Article
- Cohort profile: The DIabetes and ST-segment Elevation Myocardial Infarction (DISTEMI) Study.Cardiovascular diabetology · 2026Observational
- Protocol for a prospective cohort study for the assessment of sarcopenia in gestational diabetes: the SiGnal-D study.BMJ open · 2026Article
- Lipoprotein(a), Insulin Resistance, and Cardiovascular Disease in the UK Biobank.Journal of the American Heart Association · 2026Article
- Combination of triglyceride-glucose index and waist-to-height ratio as a predictor of all-cause and cardiovascular mortality in adults with diabetes or prediabetes: a nationwide prospective cohort study.Cardiovascular diagnosis and therapy · 2025Article
- TheInternational journal of molecular sciences · 2025Article
- Early prediction of gestational diabetes mellitus: the role of the pregnancy-specific triglycerides-glucose index and other fasting parameters in combination with dynamic testing.Acta diabetologica · 2025Article
- Tissue-specific and whole-body insulin sensitivity by integrated imaging and hyperinsulinemic euglycemic clamp: A repeatability study in people with T2DM and overweight/obesity.EJNMMI research · 2025Article
- METAB-HTX: prospective, longitudinal cohort study evaluating cardiac and systemic metabolism after heart transplantation.ESC heart failure · 2025Article
- Association between triglyceride glucose-body mass index and gestational diabetes mellitus: a prospective cohort study.BMC pregnancy and childbirth · 2025Article
- Association between cardiometabolic index and gestational diabetes mellitus: a cross-sectional study.Endocrine · 2025Article
- Association between triglyceride-glucose related indices and all-cause and cause-specific mortality in the general population: a cohort study.Cardiovascular diabetology · 2024Article
- Glucometabolism in Kidney Transplant Recipients with and without Posttransplant Diabetes: Focus on Beta-Cell Function.Biomedicines · 2024Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 5 countries.
Funding
Abstract
aims/hypothesisThe euglycaemic-hyperinsulinaemic clamp is the gold-standard method for measuring insulin sensitivity, but is less suitable for large clinical trials. Thus, several indices have been developed for evaluating insulin sensitivity from the oral glucose tolerance test (OGTT). However, most of them yield values different from those obtained by the clamp method. The aim of this study was to develop a new index to predict clamp-derived insulin sensitivity (M value) from the OGTT-derived oral glucose insulin sensitivity index (OGIS).
methodsWe analysed datasets of people that underwent both a clamp and an OGTT or meal test, thereby allowing calculation of both the M value and OGIS. The population was divided into a training and a validation cohort (n = 359 and n = 154, respectively). After a stepwise selection approach, the best model for M value prediction was applied to the validation cohort. This cohort was also divided into subgroups according to glucose tolerance, obesity category and age.
resultsThe new index, called PREDIcted M (PREDIM), was based on OGIS, BMI, 2 h glucose during OGTT and fasting insulin. Bland-Altman analysis revealed a good relationship between the M value and PREDIM in the validation dataset (only 9 of 154 observations outside limits of agreement). Also, no significant differences were found between the M value and PREDIM (equivalence test: p < 0.0063). Subgroup stratification showed that measured M value and PREDIM have a similar ability to detect intergroup differences (p < 0.02, both M value and PREDIM). CONCLUSIONS/
interpretationThe new index PREDIM provides excellent prediction of M values from OGTT or meal data, thereby allowing comparison of insulin sensitivity between studies using different tests.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.