ArticleThe journal of nutrition, health & aging2018
Osteoarthristis Increases the Risk of Cardiovascular Disease: Data from the Osteoarthritis Initiative.
Article in The journal of nutrition, health & aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Colchicine for the primary prevention of cardiovascular events.The Cochrane database of systematic reviews · 2025Pooled it
- The role of comprehensive geriatric assessment in older patients affected by knee osteoarthritis: an exploratory randomized controlled trial.Aging clinical and experimental research · 2025Trial
- Trained immunity in chronic, relapsing and low-grade joint inflammation.Nature reviews. Rheumatology · 2026Review
- Arthritis and increased risk of cardiovascular disease: is there an interaction with other chronic diseases? A nationwide cohort study.BMC cardiovascular disorders · 2025Article
- Association between neutrophil-lymphocyte ratio and all-cause and cardiovascular mortality in osteoarthritis patients from the NHANES 1999-2018 cohort.Scientific reports · 2025Article
- Diet in Knee Osteoarthritis-Myths and Facts.Nutrients · 2025Review
- Predicting cognitive frailty in community-dwelling older adults: a machine learning approach based on multidomain risk factors.Scientific reports · 2025Article
- Central obesity and radiographic severity are associated with symptomatic hand osteoarthritis: a population-based cross-sectional study.Rheumatology international · 2025Article
- Article
- Gender-Specific Impacts of the COVID-19 Pandemic on Orthopedic and Traumatology Care: An Analysis of Hospital Admissions and Length of Stay.Healthcare (Basel, Switzerland) · 2024Article
- Article
- Systemic osteoarthritis: the difficulty of categorically naming a continuous condition.Aging clinical and experimental research · 2024Review
- Cross-Sectional and Longitudinal Associations of Comorbidities with Knee Symptoms and Radiographic Abnormalities of Osteoarthritis.Rheumatology and therapy · 2024Article
- Article
- Persistent high prevalence of modifiable cardiovascular risk factors among patients with osteoarthritis in the UK in 1992-2017.RMD open · 2023Article
- Association between knee osteoarthritis and the risk of cardiovascular disease and the synergistic adverse effects of lack of exercise.Scientific reports · 2023Article
- Risk of cardiovascular events in patients having had acute calcium pyrophosphate crystal arthritis.Annals of the rheumatic diseases · 2022Article
- Mesenchymal Stromal Cells in Osteoarthritis: Evidence for Structural Benefit and Cartilage Repair.Biomedicines · 2022Review
- High Estimated 24-Hour Urinary Sodium Excretion Is Related to Symptomatic Knee Osteoarthritis: A Nationwide Cross-Sectional Population-Based Study.The journal of nutrition, health & aging · 2022Article
- A Simple Nomogram for Predicting Osteoarthritis Severity in Patients with Knee Osteoarthritis.Computational and mathematical methods in medicine · 2022Article
Corrections and comments
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Authors and funding
6 authors at 6 institutions in 3 countries.
Funding
Abstract
objectivesAlthough osteoarthritis (OA) is a common condition in older adults, the role of OA in increasing cardiovascular disease (CVD) incidence is still debated. The aim of this study was to investigate the association between OA and the onset of CVD in a large database of American adults.
designLongitudinal.
settingCommunity-dwelling.
participantsPeople with OA or at high risk of OA. MEASUREMENTS: Osteoarthritis was defined as the presence of OA of the hand, knee, hip, back/neck or of other sites. CVD was defined as self-reported presence of heart attack, heart failure, stroke and other cerebral atherosclerotic conditions, and peripheral artery disease.
resultsA total 4,265 persons without CVD (mean age=60.8 years, females=59.2%) at baseline were analyzed (1,775 with OA versus 2,490 without). Over a mean of 8.2 years, according to an adjusted Cox's regression analysis for 11 potential baseline confounders, study participants with OA of any joint had a significantly higher risk of developing CVD compared to those without OA (Hazard ratio (HR): =1.27; 95% CI: 1.03-1.56). The presence of hand OA was associated with a higher risk of developing CVD (HR=1.31; 95%CI: 1.01-1.68) with respect to those who had no OA. Knee, hip and back/neck OA did not, instead, increase the risk of developing CVD. The association between OA and CVD was significant in the women, but not in the men.
conclusionsOA, in particular, when it affects the hand and in women, was associated with a higher risk of developing CVD.
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Registered trials
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