ArticleMetallomics : integrated biometal science2018
The teleos of metallo-reduction and metallo-oxidation in eukaryotic iron and copper trafficking.
Article in Metallomics : integrated biometal science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Microbial metal physiology: ions to ecosystems.Nature reviews. Microbiology · 2025Review
- Article
- Metals at the Host-Fungal Pathogen Battleground.Annual review of microbiology · 2024Review
- Iron Homeostasis in Insects.Annual review of entomology · 2023Review
- Phenotypic analyses, protein localization, and bacteriostatic activity of Drosophila melanogaster transferrin-1.Insect biochemistry and molecular biology · 2022Article
- Low-Molecular-Weight Fe(III) Complexes for MRI Contrast Agents.Molecules (Basel, Switzerland) · 2022Review
- Bacterial-type ferroxidase tunes iron-dependent phosphate sensing during Arabidopsis root development.Current biology : CB · 2022Article
- Using a monocopper-superoxo complex to prepare multicopper-peroxo species relevant to proposed enzyme intermediates.Journal of inorganic biochemistry · 2021Article
- The iron chelator, PBT434, modulates transcellular iron trafficking in brain microvascular endothelial cells.PloS one · 2021Article
- A holistic view of mammalian (vertebrate) cellular iron uptake.Metallomics : integrated biometal science · 2020Review
- Cu Homeostasis in Bacteria: The Ins and Outs.Membranes · 2020Review
- Modulating the Properties of Fe(III) Macrocyclic MRI Contrast Agents by Appending Sulfonate or Hydroxyl Groups.Molecules (Basel, Switzerland) · 2020Article
- A Class of FeAngewandte Chemie (International ed. in English) · 2020Article
- Deregulated High Affinity Copper Transport Alters Iron Homeostasis inFrontiers in plant science · 2020Article
- MRI and fluorescence studies of Saccharomyces cerevisiae loaded with a bimodal Fe(III) TJournal of inorganic biochemistry · 2019Article
- TheProceedings of the National Academy of Sciences of the United States of America · 2019Article
- The Altered Expression ofFrontiers in plant science · 2019Article
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1 author at 1 institution in 1 country.
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Abstract
Eukaryotic cells, whether free-living or organismal, rely on metallo-reductases to process environmental ferric iron and cupric copper prior to uptake. In addition, some free-living eukaryotes (e.g. fungi and algae) couple ferri-reduction to ferro-oxidation, a process catalyzed by a small cohort of multi-copper oxidases; in these organisms, the ferric iron product is a ligand for cell iron uptake via a ferric iron permease. In addition to their support of iron uptake in lower eukaryotes, ferroxidases support ferrous iron efflux in Chordata; in this process the release of the ferrous iron from the efflux transporter is catalyzed by its ferroxidation. Last, ferroxidases also catalyze the oxidation of cuprous copper and, as metallo-oxidases, mirror the dual activity of the metallo-reductases. This Perspective examines the teleos of the yin-yang of this redox cycling of iron and copper in their metabolism.
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