Evidence map›Paper›PMID 29484298›Full record

ArticleFrontiers in nutrition2018

Improved Exercise Tolerance with Caffeine Is Associated with Modulation of both Peripheral and Central Neural Processes in Human Participants.

Joanna L Bowtell, Magni Mohr, Jonathan Fulford, Sarah R Jackman, Georgios Ermidis, Peter Krustrup, Katya N Mileva

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.

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  6. Caffeine, but not paracetamol (acetaminophen), enhances muscular endurance, strength, and power.Journal of the International Society of Sports Nutrition · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 5 countries.

Joanna L BowtellSport and Health Sciences, College of Life and Environmental Sciences, Exeter University, Exeter, United Kingdom.
Magni MohrSport and Health Sciences, College of Life and Environmental Sciences, Exeter University, Exeter, United Kingdom.
Jonathan FulfordExeter NIHR Clinical Research Facility, Medical School, University of Exeter, Exeter, United Kingdom.
Sarah R JackmanSport and Health Sciences, College of Life and Environmental Sciences, Exeter University, Exeter, United Kingdom.
Georgios ErmidisSport and Health Sciences, College of Life and Environmental Sciences, Exeter University, Exeter, United Kingdom.
Peter KrustrupSport and Health Sciences, College of Life and Environmental Sciences, Exeter University, Exeter, United Kingdom.
Katya N MilevaSport and Exercise Science Research Centre, School of Applied Science, London South Bank University, London, United Kingdom.
University of Exeter · GBLondon South Bank University · GBParthenope University of Naples · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCaffeine has been shown to enhance exercise performance and capacity. The mechanisms remain unclear but are suggested to relate to adenosine receptor antagonism, resulting in increased central motor drive, reduced perception of effort, and altered peripheral processes such as enhanced calcium handling and extracellular potassium regulation. Our aims were to investigate how caffeine (i) affects knee extensor PCr kinetics and pH during repeated sets of single-leg knee extensor exercise to task failure and (ii) modulates the interplay between central and peripheral neural processes. We hypothesized that the caffeine-induced extension of exercise capacity during repeated sets of exercise would occur despite greater disturbance of the muscle milieu due to enhanced peripheral and corticospinal excitatory output, central motor drive, and muscle contractility.

methodsNine healthy active young men performed five sets of intense single-leg knee extensor exercise to task failure on four separate occasions: for two visits (6 mg·kg

resultsThe total exercise time was 17.9 ± 6.0% longer in the caffeine (1,225 ± 86 s) than in the placebo trial (1,049 ± 73 s,

conclusionCaffeine supplementation improved high-intensity exercise tolerance despite greater-end exercise knee extensor phosphocreatine depletion and H

Indexed as

caffeinecentral fatiguefatigueneuromuscular functiontranscranial magnetic stimulation

Identifiers

PMID29484298
PMCPMC5816050
OpenAlexW2793825696

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.