Evidence map›Paper›PMID 29484273›Full record

ArticleBrain and behavior2018

Home versus hospital immunoglobulin treatment for autoimmune neuropathies: A cost minimization analysis.

Gwendal Le Masson, Guilhem Solé, Claude Desnuelle, Emilien Delmont, Marc Gauthier-Darnis, Sophie Puget, Isabelle Durand-Zaleski

Open access · goldAbstract readComparative Study
In one paragraph

Article in Brain and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Gwendal Le MassonNeuromuscular Diseases Department University Hospital Pellegrin Bordeaux France.ORCID 0000-0002-5902-9874
Guilhem SoléNeuromuscular Diseases Department University Hospital Pellegrin Bordeaux France.
Claude DesnuelleNeuromuscular Diseases Department University Hospital L'Archet Nice France.
Emilien DelmontNeuromuscular Diseases Department University Hospital La Timone Marseille France.
Marc Gauthier-DarnisMarket Access and Pricing Department LFB Biomedicaments Les Ulis France.
Sophie PugetInternational Scientific Affairs Unit LFB Biomedicaments Les Ulis France.
Isabelle Durand-ZaleskiPublic Health, AP-HPUniversity Paris Est Creteil, & ECEVE UMR 1123 Paris France.ORCID 0000-0002-4078-1476
Hôpital Pellegrin · FRLFB (France) · FRHôpital de la Timone · FRHôpital l'Archet · FRUniversité Paris-Est Créteil · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Prior clinical trials have suggested that home-based Ig treatment in multifocal motor neuropathy (MMN) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and its variant Lewis-Sumner syndrome (LSS) is safe and effective and is less costly than hospital-administered intravenous immunoglobulin (IVIg). Methods: A French prospective, dual-center, cost minimization analysis was carried out to evaluate IVIg administration (5% concentrated) at home versus in hospital with regard to costs, patients' autonomy, and patients' quality of life. The primary endpoint was the overall cost of treatment, and we adopted the perspective of the payer (French Social Health Insurance). Results: Twenty-four patients aged 52.3 (12.2) years were analyzed: nine patients with MMN, eight with CIDP, and seven with LSS. IVIg (g/kg) dosage was 1.51 ± 0.43 in hospital and 1.52 ± 0.4 at home. Nine-month total costs per patient extrapolated to 1 year of treatment were €48,189 ± 26,105 versus €91,798 ± 51,125 in the home and hospital groups, respectively ( Discussion: The switch from hospital-based to home-based IVIg treatment for patients with immune neuropathy represents potentially significant savings in the management of the disease.

Indexed as

Immunoglobulins, IntravenousPolyneuropathiesPolyradiculoneuropathy, Chronic Inflammatory DemyelinatingQuality of LifeAdultAutoimmunityCosts and Cost AnalysisFemaleFranceHome Care ServicesHospitalizationHumansMaleMiddle AgedProspective StudiesImmunoglobulins, Intravenouscosthome careimmune neuropathiesimmunoglobulins

Identifiers

PMID29484273
PMCPMC5822576
OpenAlexW2791651392

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.