Evidence map›Paper›PMID 29484263›Full record

ArticleBrain and behavior2018

Neurodegenerative disease biomarkers Aβ

Jason A Chen, Scott C Fears, Anna J Jasinska, Alden Huang, Noor B Al-Sharif, Kevin E Scheibel, Thomas D Dyer, Anne M Fagan, John Blangero, Roger Woods and 4 more

Open access · goldAbstract read
In one paragraph

Article in Brain and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Article
  3. Exploratory Dual PET imaging of [Bioorganic & medicinal chemistry letters · 2024
    Article
  4. Suppressing UBE2N ameliorates Alzheimer's disease pathology through the clearance of amyloid beta.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
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  18. A nonhuman primate model of early Alzheimer's disease pathologic change: Implications for disease pathogenesis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2019
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Jason A ChenDepartment of Psychiatry The Jane and Terry Semel Institute for Neuroscience and Human Behavior David Geffen School of Medicine University of California Los Angeles CA USA.ORCID 0000-0003-3158-9471
Scott C FearsDepartment of Psychiatry The Jane and Terry Semel Institute for Neuroscience and Human Behavior David Geffen School of Medicine University of California Los Angeles CA USA.
Anna J JasinskaDepartment of Psychiatry The Jane and Terry Semel Institute for Neuroscience and Human Behavior David Geffen School of Medicine University of California Los Angeles CA USA.
Alden HuangDepartment of Psychiatry The Jane and Terry Semel Institute for Neuroscience and Human Behavior David Geffen School of Medicine University of California Los Angeles CA USA.
Noor B Al-SharifDepartment of Psychiatry The Jane and Terry Semel Institute for Neuroscience and Human Behavior David Geffen School of Medicine University of California Los Angeles CA USA.
Kevin E ScheibelDepartment of Psychiatry The Jane and Terry Semel Institute for Neuroscience and Human Behavior David Geffen School of Medicine University of California Los Angeles CA USA.
Thomas D DyerSouth Texas Diabetes and Obesity Institute University of Texas Rio Grande Valley School of Medicine Brownsville TX USA.
Anne M FaganDepartment of Neurology Washington University in St. Louis St. Louis MO USA.
John BlangeroSouth Texas Diabetes and Obesity Institute University of Texas Rio Grande Valley School of Medicine Brownsville TX USA.
Roger WoodsDepartment of Psychiatry The Jane and Terry Semel Institute for Neuroscience and Human Behavior David Geffen School of Medicine University of California Los Angeles CA USA.
Matthew J JorgensenDepartment of Pathology Section on Comparative Medicine Wake Forest School of Medicine Winston-Salem NC USA.
Jay R KaplanDepartment of Pathology Section on Comparative Medicine Wake Forest School of Medicine Winston-Salem NC USA.
Nelson B FreimerDepartment of Psychiatry The Jane and Terry Semel Institute for Neuroscience and Human Behavior David Geffen School of Medicine University of California Los Angeles CA USA.
Giovanni CoppolaDepartment of Psychiatry The Jane and Terry Semel Institute for Neuroscience and Human Behavior David Geffen School of Medicine University of California Los Angeles CA USA.ORCID 0000-0003-2105-1061
University of California, Los Angeles · USThe University of Texas Rio Grande Valley · USWake Forest University · USWashington University in St. Louis · USWest Los Angeles College · US

Funding

The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI HEAD, DENISE · 2005 to 2025
$49.5M
UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
Vervet Research Colony as a Biomedical ResourceP40OD010965 · OD · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Matthew Jorgensen · 2012 to 2026
$14.6M
Integrative Center for Neurogenetics and Neurogenomics - OverallP30NS062691 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COPPOLA, GIOVANNI · 2009 to 2018
$7.4M
VERVET RESEARCH COLONY AS A BIOMEDICAL RESOURCE: AIDSP40RR019963 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KAPLAN, JAY ROSS · 2005 to 2011
$6.2M
Genetic Determinants of TauopathiesF31NS084556 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHEN, JASON ANDREW · 2013 to 2015
$80k
NCRR NIH HHS P40 RR019963NIA NIH HHS P01 AG026276NIH HHS P40 OD010965NINDS NIH HHS F31 NS084556NINDS NIH HHS P30 NS062691
6 · The paper itself

Abstract

Background: The Caribbean vervet monkey ( Methods: To characterize biomarkers associated with neurodegeneration, we measured cerebrospinal fluid (CSF) concentrations of Aβ Results: Aβ Conclusions: Overall, these results support the vervet as a non-human primate model of amyloid-related neurodegeneration, such as Alzheimer's disease and cerebral amyloid angiopathy, and highlight Aβ

Indexed as

AgingAmyloid beta-PeptidesCerebral Amyloid AngiopathyChlorocebus aethiopsMonkey DiseasesPeptide Fragmentstau ProteinsAlzheimer DiseaseAnimalsBiomarkersBrainChromosomes, MammalianFemaleGenetic LinkageGenome-Wide Association StudyMaleAmyloid beta-Peptidesamyloid beta-protein (1-40)BiomarkersPeptide Fragmentstau ProteinsAlzheimer's diseaseamyloid betacerebral amyloid angiopathycerebrospinal fluidtauvervet

Identifiers

PMID29484263
PMCPMC5822592
OpenAlexW2783641581

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.