ArticleBrain and behavior2018
Relationship between serum vitamin D levels and inflammatory markers in acute stroke patients.
Article in Brain and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Association Between Peripheral IL-6 Levels in the Acute Stage of Stroke and Poststroke Depression: A Systematic Review and Meta-Analysis.Brain and behavior · 2026Pooled it
- Association of a low vitamin D status with risk of post-stroke depression: A meta-analysis and systematic review.Frontiers in nutrition · 2023Pooled it
- Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Poststroke Depression: A Systematic Review and Meta-Analysis.Disease markers · 2022Pooled it
- Prognostic utility of serum 25-hydroxyvitamin D in patients with stroke: a meta-analysis.Journal of neurology · 2020Pooled it
- Exploring the Association of Vitamin D and VDR Polymorphisms with Disease Severity in COVID-19 and Influenza.Biomedicines · 2025Article
- Increased C-Reactive Protein in Patients with Post-Stroke Depression: A Meta-analysis of Cohort Study.Alpha psychiatry · 2024Review
- Effect of High-dose Vitamin D on IL-1β Blood Level in Patients with Moderate Stroke: A Randomized Clinical Trial.Anesthesiology and pain medicine · 2023Article
- Brain changes in neuroimaging of adult patients with vitamin D deficiency: systematic review protocol.BMJ open · 2023Article
- Association of Long Non-Coding RNA Malat1 with Serum Levels of Interleukin-1 Beta and Vitamin D in Patients with Ischemic Stroke.Galen medical journal · 2023Article
- The pathogenesis of post-stroke osteoporosis and the role oxidative stress plays in its development.Frontiers in medicine · 2023Review
- Protective Effect of Vitamin D Supplementation on Some Hemogram Derived Inflammatory Indices in Normal and High-Fat Diet Fed Male Wistar Rats.International journal of preventive medicine · 2023Article
- Gender-related differences in the association of serum levels of vitamin D with body mass index in northern Iranian population: the PERSIAN Guilan Cohort Study (PGCS).BMC nutrition · 2022Article
- Surrogate biomarkers of outcome for wake-up ischemic stroke.BMC neurology · 2022Article
- The relation of common inflammatory cytokines with anxiety and depression and their values in estimating cardiovascular outcomes in coronary heart disease patients.Journal of clinical laboratory analysis · 2022Article
- Vitamin D serum level predicts stroke clinical severity, functional independence, and disability-A retrospective cohort study.Frontiers in neuroscience · 2022Article
- Stroke-Induced Peripheral Immune Dysfunction in Vitamin D-Deficient Conditions: Modulation by Progesterone and Vitamin D.Molecular neurobiology · 2021Article
- Does vitamin D administration play a role in outcome of patients with acute ischemic stroke? A randomized controlled trial.Current journal of neurology · 2021Article
- The Role of Vitamin D in the Relationship Between Gender and Deep Vein Thrombosis Among Stroke Patients.Frontiers in nutrition · 2021Article
- Article
- Vitamin D Deficiency and the Risk of Cerebrovascular Disease.Antioxidants (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Low serum vitamin D levels are associated with the development of poststroke depression (PSD). Inflammatory markers play an important role in pathophysiology of PSD. The relationship between vitamin D levels and inflammatory markers has been discussed in nonstroke individuals. The purposes of this study were to explore the relationship between vitamin D levels and inflammatory markers in acute stroke patients and examine the effect of vitamin D and inflammatory markers on PSD. Methods: A total of 152 acute stroke patients were recruited. Serum levels of 25-hydroxyvitamin D and inflammatory markers were measured by standardized laboratory methods. Depression symptoms were assessed with the 17-item Hamilton Depression Scale (HAMD-17). Patients with the HAMD-17 scores ≥7 were identified to have depression symptoms. Results: Serum vitamin D levels were negatively correlated with serum levels of interleukin-6 and high-sensitivity C-reactive protein (hsCRP) ( Conclusions: Serum vitamin D levels are inversely associated with the levels of interleukin-6 and hsCRP, suggesting a potential anti-inflammatory role for vitamin D in stroke individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.