Evidence map›Paper›PMID 29484228›Full record

ArticleTurkish journal of urology2018

The adverse effects of oral desmopressin lyophilisate (MELT): personal experience on enuretic children.

Pietro Ferrara, Giulia Franceschini, Serena Mercurio, Ester Del Vescovo, Francesca Ianniello, Tommasangelo Petitti

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Article in Turkish journal of urology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pietro FerraraInstitute of Pediatrics, Catholic University Medical School, Rome, Italy.
Giulia FranceschiniService of Pediatrics, Campus Bio-Medico University, Rome, Italy.
Serena MercurioService of Pediatrics, Campus Bio-Medico University, Rome, Italy.
Ester Del VescovoService of Pediatrics, Campus Bio-Medico University, Rome, Italy.
Francesca IannielloInstitute of Pediatrics, Catholic University Medical School, Rome, Italy.
Tommasangelo PetittiPublic Health and Statistics, Campus Bio-Medico University, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to evaluate adverse effects of oral desmopressin lyophilisate (MELT) in enuretic children. MATERIAL AND

methodsWe enrolled 260 children with nocturnal enuresis (NE) referred to the Pediatric Service, 'Campus Bio-Medico' University of Rome, from April 2014 to April 2017 in the study, of these 23 were excluded. The study was characterized by 2 phases. During Phase 1 a careful patient's medical history was obtained and physical examination was performed. After 3 months of treatment with MELT (Minirin/DDAVP

resultsAmong 237 patients included in the study 11 male and 6 female (n=17; 7.2%) patients with a mean age 10.06±2.49 years, reported 22 adverse effects, with an absolute risk of 7.17%. In particular, 5 neurological symptoms, 3 gastrointestinal effects, 4 sleep disturbances, 8 psycho-behavioral disorders, 2 symptoms of fatigue were reported.

conclusionIn our study MELT with its higher bioavailability guaranteed lower frequency of adverse effects which resolved spontaneously and rapidly. The MELT formulation actually represents the first line and safe treatment for the NE.

Indexed as

Adverse effectsdesmopressinenuresis

Identifiers

PMID29484228
PMCPMC5821283

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