Evidence map›Paper›PMID 29484215›Full record

ArticleJournal of analytical methods in chemistry2018

Simple and Selective HPLC-UV/Vis Bioanalytical Method to Determine Aluminum Phthalocyanine Chloride in Skin Permeation Studies.

Thaiene Avila Reis, Ana Elise Jaculi, Rubens da Costa Alves, Tais Gratieri, Ricardo Bentes Azevedo, Graziella Anselmo Joanitti, Guilherme Martins Gelfuso, Marcilio Cunha-Filho

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In one paragraph

Article in Journal of analytical methods in chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Thaiene Avila ReisLaboratory of Food, Drugs and Cosmetics (LTMAC), School of Health Sciences, University of Brasília, 70.910-900 Brasília, DF, Brazil.
Ana Elise JaculiLaboratory of Food, Drugs and Cosmetics (LTMAC), School of Health Sciences, University of Brasília, 70.910-900 Brasília, DF, Brazil.
Rubens da Costa AlvesLaboratory of Food, Drugs and Cosmetics (LTMAC), School of Health Sciences, University of Brasília, 70.910-900 Brasília, DF, Brazil.
Tais GratieriLaboratory of Food, Drugs and Cosmetics (LTMAC), School of Health Sciences, University of Brasília, 70.910-900 Brasília, DF, Brazil.ORCID 0000-0001-6481-2364
Ricardo Bentes AzevedoDepartment of Genetics and Morphology, Institute of Biological Sciences, University of Brasília, 70.910-900 Brasília, DF, Brazil.
Graziella Anselmo JoanittiFaculty of Ceilandia, University of Brasília, 72.220-900 Brasília, DF, Brazil.
Guilherme Martins GelfusoLaboratory of Food, Drugs and Cosmetics (LTMAC), School of Health Sciences, University of Brasília, 70.910-900 Brasília, DF, Brazil.
Marcilio Cunha-FilhoLaboratory of Food, Drugs and Cosmetics (LTMAC), School of Health Sciences, University of Brasília, 70.910-900 Brasília, DF, Brazil.ORCID 0000-0002-9167-6852
Universidade de Brasília · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Considering the feasibility of the aluminum phthalocyanine chloride (AlPcCl) application in the topical photodynamic therapy of cutaneous tumors and the lack of HPLC methods capable of supporting skin permeation experiments using this compound, the aim of this study was to obtain a simple and selective chromatographic method for AlPcCl determination in skin matrices. A HPLC-UV/Vis method was developed using a normal-phase column operating at 30°C, an isocratic mobile phase of methanol : phosphoric acid (0.01 M) at 1.5 mL/min, and detection at 670 nm. The method exhibited (i) selectivity against various contaminants found in the different skin layers, (ii) high drug extraction capacity from the hair follicle (>70%) and remaining skin (>80%), and (iii) low limits of detection and of quantification (0.03 and 0.09

Identifiers

PMID29484215
PMCPMC5816864
OpenAlexW2785766763

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.