ArticleClinical & translational immunology2018
Accumulation of IL-17
Article in Clinical & translational immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Gamma delta (γδ) T cells in the female reproductive tract: active participants or indifferent bystanders in reproductive success?Discovery immunology · 2024Review
- Single-Cell RNA-Sequencing Reveals Interactions between Endometrial Stromal Cells, Epithelial Cells, and Lymphocytes during Mouse Embryo Implantation.International journal of molecular sciences · 2022Article
- Role of hormones in the pregnancy and sex-specific outcomes to infections with respiratory viruses.Immunological reviews · 2022Review
- γδ T Cells in Brain Homeostasis and Diseases.Frontiers in immunology · 2022Review
- γδ T cells in tissue physiology and surveillance.Nature reviews. Immunology · 2021Review
- Activated γδ T Cells With Higher CD107a Expression and Inflammatory Potential During Early Pregnancy in Patients With Recurrent Spontaneous Abortion.Frontiers in immunology · 2021Article
- Cytokines, Hormones and Cellular Regulatory Mechanisms Favoring Successful Reproduction.Frontiers in immunology · 2021Review
- γδ T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis.Mucosal immunology · 2020Article
- Bacterial-induced maternal interleukin-17A pathway promotes autistic-like behaviors in mouse offspring.Experimental animals · 2020Article
- BuShen HuoXue Decoction Promotes Decidual Stromal Cell Proliferation via the PI3K/AKT Pathway in Unexplained Recurrent Spontaneous Abortion.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Asthma and/or hay fever as predictors of fertility/impaired fecundity in U.S. women: National Survey of Family Growth.Scientific reports · 2019Article
- The role of maternal T cell and macrophage activation in preterm birth: Cause or consequence?Placenta · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Pregnancy is an immune paradox. While the immune system is required for embryo implantation, placental development and progression of gestation, excessive inflammation is associated with pregnancy failure. Similarly, the cytokine IL-17A plays an important role in defence against extracellular pathogens, but its dysregulation can lead to pathogenic inflammation and tissue damage. Although expression of IL-17 has been reported during pregnancy, the cellular source of this cytokine and its relevance to gestation are not clear. Objectives: Here we define the kinetics and cellular source of IL-17A in the uterus during healthy and abortion-prone murine pregnancy. Methods: The CBA/J x DBA/2J abortion-prone mating was used and compared to CBA/J x BALB/c control mating. Results: We demonstrate that, irrespective of gestational health, the number of IL-17-producing cells peaks during midterm pregnancy and is largely derived from the γδ T-cell lineage. We identify γδ T, Th17, CD8 T and NKT cells as the cellular source of IL-17A in pregnant mice. Furthermore, we positively identify the Vγ6 Conclusions: To conclude, the accumulation of uterine IL-17
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.