Evidence map›Paper›PMID 29483979›Full record

ArticleOpen access Macedonian journal of medical sciences2018

Micro - Focused Phototherapy Associated To Janus Kinase Inhibitor: A Promising Valid Therapeutic Option for Patients with Localized Vitiligo.

Serena Gianfaldoni, Georgi Tchernev, Uwe Wollina, Maria Grazia Roccia, Massimo Fioranelli, Jacopo Lotti, Miriam Rovesti, Francesca Satolli, Yan Valle, Andy Goren and 5 more

Abstract read
In one paragraph

Article in Open access Macedonian journal of medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. A systematic review of case series and clinical trials investigating systemic oral or injectable therapies for the treatment of vitiligo.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Pooled it
  3. Review
  4. Review
  5. Tofacitinib as a Promising Therapeutic Option for Vitiligo: A Systematic Review.Clinical, cosmetic and investigational dermatology · 2026
    Review
  6. Article
  7. Review
  8. Review
  9. Vitiligo: Pathogenesis and New and Emerging Treatments.International journal of molecular sciences · 2023
    Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Vitiligo: What's old, what's new.Dermatology reports · 2021
    Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Serena GianfaldoniUniversity G. Marconi of Rome - Dermatology and Venereology, University G. Marconi of Rome, Rome, Italy.
Georgi TchernevMedical Institute of Ministry of Interior (MVR), Department of Dermatology, Venereology and Dermatologic Surgery, Sofia, Bulgaria.
Uwe WollinaStädtisches Klinikum Dresden, Department of Dermatology and Venereology, Dresden, Sachsen, Germany.
Maria Grazia RocciaUniversity B.I.S. Group of Institutions, Punjab Technical University, Punjab, India.
Massimo FioranelliG. Marconi University - Department of Nuclear Physics, Subnuclear and Radiation, Rome, Italy.
Jacopo LottiG. Marconi University - Department of Nuclear Physics, Subnuclear and Radiation, Rome, Italy.
Miriam RovestiDepartment of Dermatology, University of Parma, Parma, Italy.
Francesca SatolliDepartment of Dermatology, University of Parma, Parma, Italy.
Yan ValleVitiligo Research Foundation, New York, United States.
Andy GorenUniversity G. Marconi of Rome, Dermatology and Venereology, Rome, Italy.
Michael TirantPsoriasis & Skin Clinic, 374 Nepean Highway Frankston Victoria, Melbourne 3199, Australia.
Mirna SitumDepartment of Dermato-Venereology, Zagreb University Hospital Center Sisters of Charity, University of Zagreb, Zagreb, Croatia.
Maja KovacevicUniversity G. Marconi of Rome, Dermatology and Venereology, Rome, Italy.
Katlein FrançaUniversity of Miami School of Medicine, Miami, Florida, United States.
Torello LottiUniversity G. Marconi of Rome, Dermatology and Venereology, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitiligo is an acquired pigmentary cutaneous disease, characterised by the progressive loss of melanocytes, resulting in hypopigmented skin areas which progressively become amelanotic. Classically, vitiligo treatments are unsatisfactory and challenging. Despite the continuous introduction of new therapies, phototherapy is still the mainstay for vitiligo repigmentation.

aimThe aim of this multicenter observational retrospective study was to evaluate the efficacy and safety of the nb - UVB micro - phototherapy (BIOSKIN EVOLUTION®), used alone or in associations with an oral Janus kinase inhibitor (Tofacitinib citrate), in the treatment of stable or active forms of localised vitiligo. MATERIAL AND

methodsFifty eight patients had been treated with n-UVB micro-photootherapy (Group A); 9 patients had been treated with phototherapy plus Tofacitinb citrate (Group B).

resultsAmong Group A, 42 patients (72%) obtained a re-pigmentation rate higher than 75%, with a medium value of 77%. 11 patients (19%) achieved a marked improvement of the clinical findings with a repigmentation rate between 50-75%; 4 patients (8%) showed a moderate response with a lesional repigmentation of 25-50%. Only one patient (1%) had a poor response to the phototherapeutic treatment.

conclusionNb - UVB micro-focused phototherapy is one of the most effective therapeutic options for vitiligo treatment. The association of micro-focused phototherapy to Tofacitinib citrate seems to provide better clinical results in term of repigmentation rate.

Indexed as

BIOSKIN EVOLUTION®Janus kinase inhibitorMicro – phototherapyRepigmentationTofacitinibVitiligo

Identifiers

PMID29483979
PMCPMC5816312

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.