Evidence map›Paper›PMID 29483909›Full record

ArticleFrontiers in immunology2018

Agonistic Autoantibodies to the β2-Adrenergic Receptor Involved in the Pathogenesis of Open-Angle Glaucoma.

Anselm Jünemann, Bettina Hohberger, Jürgen Rech, Ahmed Sheriff, Qin Fu, Ursula Schlötzer-Schrehardt, Reinhard Edmund Voll, Sabine Bartel, Hubert Kalbacher, Johan Hoebeke and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 34 citations in OpenAlex.

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  10. Review
  11. Concise Synthesis of Both Enantiomers of Pilocarpine.Molecules (Basel, Switzerland) · 2021
    Article
  12. [The role of citicoline in glaucoma].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2021
    Review
  13. [Rho kinase inhibitors as new local therapy option in primary open angle glaucoma].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2021
    Review
  14. Article
  15. Article
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  17. Article
  18. AgonisticFrontiers in immunology · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 4 countries.

Anselm JünemannDepartment of Ophthalmology, University of Rostock, Rostock, Germany.
Bettina HohbergerDepartment of Ophthalmology, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen, Germany.
Jürgen RechDepartment of Internal Medicine III, Institute of Clinical Immunology and Rheumatology, University of Erlangen-Nürnberg, Erlangen, Germany.
Ahmed SheriffDepartment of Internal Medicine III, Institute of Clinical Immunology and Rheumatology, University of Erlangen-Nürnberg, Erlangen, Germany.
Qin FuDepartment of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Ursula Schlötzer-SchrehardtDepartment of Ophthalmology, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen, Germany.
Reinhard Edmund VollIZKF Research Group 2, Nikolaus-Fiebiger-Center of Molecular Medicine, University of Erlangen-Nürnberg, Erlangen, Germany.
Sabine BartelMax Delbrück Center for Molecular Medicine, Berlin, Germany.
Hubert KalbacherIFIB - Institute of Biochemistry, University of Tübingen, Tübingen, Germany.
Johan HoebekeC.N.R.S. UPR 9021 «Chimie et Immunologie Thérapeutiques», Strasbourg, France.
Robert RejdakDepartment of General Ophthalmology, Medical University of Lublin, Lublin, Poland.
Folkert HornDepartment of Ophthalmology, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen, Germany.
Gerd WallukatMax Delbrück Center for Molecular Medicine, Berlin, Germany.
Rudolf KunzeScience Office, Berlin-Buch, Campus Max Delbrück Center for Molecular Medicine, Berlin, Germany.
Martin HerrmannDepartment of Internal Medicine III, Institute of Clinical Immunology and Rheumatology, University of Erlangen-Nürnberg, Erlangen, Germany.
Friedrich-Alexander-Universität Erlangen-Nürnberg · DEMax Delbrück Center · DEHuazhong University of Science and Technology · CNImmunologie, Immunopathologie et Chimie Thérapeutique · FRMedical University of Lublin · PLUniversity of Rostock · DEUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glaucoma is a frequent ocular disease that may lead to blindness. Primary open-angle glaucoma (POAG) and ocular hypertension (OHT) are common diseases with increased intraocular pressure (IOP), which are mainly responsible for these disorders. Their pathogenesis is widely unknown. We screened the sera of patients with POAG and OHT for the prevalence of autoantibodies (AAb) against G protein-coupled receptors (GPCRs) in comparison to controls. Employing frequency modulation of spontaneously contracting neonatal rat cardiomyocytes

Indexed as

AdultAgedAged, 80 and overAnimalsAnimals, NewbornAutoantibodiesBinding SitesCells, CulturedFemaleGlaucoma, Open-AngleHumansImmunoglobulin GMaleMiddle AgedMyocytes, CardiacOcular HypertensionAutoantibodiesImmunoglobulin GReceptors, Adrenergic, beta-2agonisticautoantibodiesglaucomaimmunoadsorptionocular hypertensionβ2-adrenergic receptor

Identifiers

PMID29483909
PMCPMC5816038
OpenAlexW2793854316

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.