Evidence map›Paper›PMID 29483864›Full record

ArticleFrontiers in integrative neuroscience2018

Differential Regulation of Bladder Pain and Voiding Function by Sensory Afferent Populations Revealed by Selective Optogenetic Activation.

Jennifer J DeBerry, Vijay K Samineni, Bryan A Copits, Christopher J Sullivan, Sherri K Vogt, Kathryn M Albers, Brian M Davis, Robert W Gereau

Abstract read
In one paragraph

Article in Frontiers in integrative neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. From bladder to brain: How you know when it's time to go.Current opinion in neurobiology · 2025
    Review
  3. A Spinal Circuit for Modular Gating of Organ Somatosensation.bioRxiv : the preprint server for biology · 2025
    Article
  4. Emergent biotechnology applications in urology: a mini review.Frontiers in bioengineering and biotechnology · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. New era of optogenetics: from the central to peripheral nervous system.Critical reviews in biochemistry and molecular biology · 2020
    Review
  13. Review
  14. Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jennifer J DeBerryDepartment of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Vijay K SamineniDepartment of Anesthesiology, Washington University Pain Center, St. Louis, MO, United States.
Bryan A CopitsDepartment of Anesthesiology, Washington University Pain Center, St. Louis, MO, United States.
Christopher J SullivanDepartment of Neurobiology, Center for Neuroscience at the University of Pittsburgh, Pittsburgh, PA, United States.
Sherri K VogtDepartment of Anesthesiology, Washington University Pain Center, St. Louis, MO, United States.
Kathryn M AlbersDepartment of Neurobiology, Center for Neuroscience at the University of Pittsburgh, Pittsburgh, PA, United States.
Brian M DavisDepartment of Neurobiology, Center for Neuroscience at the University of Pittsburgh, Pittsburgh, PA, United States.
Robert W GereauDepartment of Anesthesiology, Washington University Pain Center, St. Louis, MO, United States.

Funding

MECHANISMS OF PERIPHERAL MGLUR MODULATION OF NOCICEPTIONR01NS042595 · NINDS · WASHINGTON UNIVERSITY · PI GEREAU, ROBERT W · 2002 to 2017
$5.2M
TRAINING PROGRAM IN ANESTHESIOLOGY RESEARCHT32GM108539 · NIGMS · WASHINGTON UNIVERSITY · PI Aaron J Norris · 2014 to 2026
$4.9M
Multimodal biocompatible microLED devices for diverse neuroscience applicationsR01NS081707 · NINDS · WASHINGTON UNIVERSITY · PI GEREAU, ROBERT W, ROGERS, JOHN · 2012 to 2016
$3.9M
Characterization and Plasticity of Visceral NociceptorsR01NS050758 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DAVIS, BRIAN M · 2005 to 2012
$2.6M
Afferent Mechanisms of Pelvic HypersensitivityR01DK093525 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GOLD, MICHAEL S · 2011 to 2014
$2.3M
Soft, conformal wireless optoelectronic systems for the long-term neuromodulation of bladder functionU18EB021793 · NIBIB · WASHINGTON UNIVERSITY · PI GEREAU, ROBERT W, ROGERS, JOHN · 2015 to 2018
$877k
Optogenetic dissection of the functional properties of bladder afferent populationsK01DK101681 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DEBERRY, JENNIFER J · 2014 to 2018
$679k
Novel viral tools for control of bladder function and painU18EB021877 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DAVIS, BRIAN M, GLORIOSO, JOSEPH C · 2015 to 2016
$607k
NIBIB NIH HHS U18 EB021793NIBIB NIH HHS U18 EB021877NIDDK NIH HHS K01 DK101681NIDDK NIH HHS R01 DK093525NIGMS NIH HHS T32 GM108539NINDS NIH HHS R01 NS042595NINDS NIH HHS R01 NS050758NINDS NIH HHS R01 NS081707
6 · The paper itself

Abstract

Bladder-innervating primary sensory neurons mediate reflex-driven bladder function under normal conditions, and contribute to debilitating bladder pain and/or overactivity in pathological states. The goal of this study was to examine the respective roles of defined subtypes of afferent neurons in bladder sensation and function

Indexed as

channelrhodopsininterstitial cystitismicturitionNav1.8optogeneticsTRPV1visceralvoiding

Identifiers

PMID29483864
PMCPMC5816063

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.