Evidence map›Paper›PMID 29483820›Full record

ArticleInternational journal of biological sciences2018

Vital Roles of β-catenin in Trans-differentiation of Chondrocytes to Bone Cells.

Yan Jing, Junjun Jing, Ke Wang, Kevin Chan, Stephen E Harris, Robert J Hinton, Jian Q Feng

Open access · goldAbstract read
In one paragraph

Article in International journal of biological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Nf2 orchestrates β-arrestin2-biased PTH1R signaling to couple bone mass with skeletal integrity.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. The effects of dietary loading on the transdifferentiation of condylar chondrocytes.American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics · 2024
    Article
  8. Article
  9. Short-term effects of mechanical loading on the transdifferentiation of condylar chondrocytes.American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Type V collagen regulates the structure and biomechanics of TMJ condylar cartilage: A fibrous-hyaline hybrid.Matrix biology : journal of the International Society for Matrix Biology · 2021
    Article
  15. Article
  16. Article
  17. ScxBone · 2021
    Article
  18. Osteocytes but not osteoblasts directly build mineralized bone structures.International journal of biological sciences · 2021
    Article
  19. Review
  20. Evidence of vasculature and chondrocyte to osteoblast transdifferentiation in craniofacial synovial joints: Implications for osteoarthritis diagnosis and therapy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yan JingDepartment of Orthodontics, Texas A&M University College of Dentistry, Dallas, TX, 75246, USA.
Junjun JingState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China, 610041.
Ke WangDepartment of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, 75246, USA.
Kevin ChanDepartment of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, 75246, USA.
Stephen E HarrisDepartment of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.
Robert J HintonDepartment of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, 75246, USA.
Jian Q FengDepartment of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, 75246, USA.
Texas A&M University · USThe University of Texas Health Science Center at San Antonio · US

Funding

Bmp2 and Sost Genes and Their Interactions in Stem Cells of the PeriodontiumR01DE024797 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HARRIS, STEPHEN EUBANK · 2015 to 2019
$1.9M
Chondrocyte-derived bone cells determine the overall pattern of TMJ condyle and contribute to bone remodelingR01DE025659 · NIDCR · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI RUEST, LOUIS-BRUNO · 2017 to 2021
$1.8M
NIDCR NIH HHS R01 DE024797NIDCR NIH HHS R01 DE025659
6 · The paper itself

Abstract

A recent breakthrough showing that direct trans-differentiation of chondrocytes into bone cells commonly occurs during endochondral bone formation in the growth plate, articular cartilage, and mandibular condylar cartilage suggests that chondrogenesis and osteogenesis are likely one continuous biological process instead of two separate processes. Yet, gene regulation of this cell transformation is largely unclear. Here, we employed cartilage-specific

Indexed as

Animalsbeta CateninCell DifferentiationCell ProliferationChondrocytesChondrogenesisMiceMice, KnockoutMice, TransgenicMicroscopy, ConfocalMicroscopy, Electron, ScanningOsteogenesisSignal Transductionbeta Catenincartilagecell signalingchondrocytegrowth/developmentosteoblast

Identifiers

PMID29483820
PMCPMC5821044
OpenAlexW2772673497

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.