ReviewInternational journal of medical sciences2018
Risks of Using Sterilization by Gamma Radiation: The Other Side of the Coin.
Review in International journal of medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 182 citations in OpenAlex.
- A γ-radiation-responsive diselenide-core micelle for on-demand delivery of cannabidiol in the mitigation of acute radiation injury.Materials today. Bio · 2026Article
- Combined High Hydrostatic Pressure and Additive Chemical Treatment Enhances Decontamination Efficiency in Bone Tissue Infected with Staphylococcal Biofilms.Microorganisms · 2026Article
- Potential of Covalent Organic Framework in Pharmacy and Biomedicine: Influence of Structure on Properties and Applications.ChemMedChem · 2026Review
- Comments on "Cryopreserved Total Skin Allografts From Living Donors for Complex Wound Management: A New Paradigm in Regenerative Wound Care".International wound journal · 2026Article
- Bioinstructive polymer fibre mats to reduce bacterial pathogen colonisation.RSC applied polymers · 2026Article
- An all-in-one injectable biocement: self-setting magnesium phosphate for bone repair, fracture adhesion and osteoporotic fixation.Regenerative biomaterials · 2026Article
- Synergistic Effects of Non-Ionizing Radiation in the Targeted Modification of Living Tissues.International journal of molecular sciences · 2025Review
- Comparative Carbon Footprint Study of Self-Monitoring Vs. Continuous Monitoring of Blood Glucose.Global challenges (Hoboken, NJ) · 2025Article
- Peripheral Nerve Decellularisation Protocol for Allogeneic Transplantation: From Tissue Procurement to Banking.International journal of molecular sciences · 2025Article
- Impact of dry heat sterilization on the mechanical and functional performance of 3D printed medical devices for image-guided intervention.Annals of 3D printed medicine · 2025Article
- Bone fusion materials: past, present, and future.Asian spine journal · 2025Article
- Advances in cheese safety and quality: harnessing irradiation technologies for enhanced preservation.Journal of food science and technology · 2025Review
- Effects of Ionizing Radiation on the Biophysical Properties of Type I Collagen Fibrils.PloS one · 2025Article
- A sterilization method for human decellularized vaginal matrices.Scientific reports · 2024Article
- Development of a sterilization process for amniotic membrane allograft tissue using supercritical carbon dioxide and NovaKill.Cell and tissue banking · 2024Article
- Effect of gamma and Ultraviolet-C sterilization on BMP-7 level of indigenously prepared demineralized freeze-dried bone allograft.Cell and tissue banking · 2024Article
- Gamma radiation-induced enhancement of biocontrol agents for plant disease management.Current research in microbial sciences · 2024Review
- Collagen molecular organization preservation in human fascia lata and periosteum after tissue engineering.Frontiers in bioengineering and biotechnology · 2024Article
- The cell-assembled extracellular matrix: A focus on the storage stability and terminal sterilization of this human "bio" material.Acta biomaterialia · 2023Article
- Development of a dual-component infection-resistant arterial replacement for small-caliber reconstructions: A proof-of-concept study.Frontiers in bioengineering and biotechnology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The standard sterilization method for most medical devices over the past 40 years involves gamma irradiation. During sterilization, gamma rays efficiently eliminate microorganisms from the medical devices and tissue allografts, but also significantly change molecular structure of irradiated products, particularly fragile biologics such as cytokines, chemokines and growth factors. Accordingly, gamma radiation significantly alters biomechanical properties of bone, tendon, tracheal, skin, amnion tissue grafts and micronized amniotic membrane injectable products. Similarly, when polymer medical devices are sterilized by gamma radiation, their physico-chemical characteristics undergo modification significantly affecting their clinical use. Several animal studies demonstrated that consummation of irradiated food provoked genome instability raising serious concerns regarding oncogenic potential of irradiated consumables. These findings strongly suggest that new, long-term, prospective clinical studies should be conducted in near future to investigate whether irradiated food is safe for human consumption. In this review, we summarized current knowledge regarding molecular mechanisms responsible for deleterious effects of gamma radiation with focusing on its significance for food safety and biomechanical characteristics of medical devices, and tissue allografts, especially injectable biologics.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.