ArticleScientific reports2018
First profiling of lysine crotonylation of myofilament proteins and ribosomal proteins in zebrafish embryos.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 60 citations in OpenAlex.
- KAT-Net: a hyperbolic routing framework for joint lysine acylation site prediction with shared sequence-structure representations.Briefings in bioinformatics · 2026Article
- Efficient control of Tribulium castaneum using zeolitic imidazolate framework-8 nanocarrier-mediated delivery of dsRNA targeting Paramyosin.Pest management science · 2026Article
- Post-translational acylation of proteins in cardiac hypertrophy.Nature reviews. Cardiology · 2025Review
- EDS-Kcr: deep supervision based on large language model for identifying protein lysine crotonylation sites across multiple species.Briefings in bioinformatics · 2025Article
- Modulation of Abnormal Vasoconstriction Through 2-Hydroxyisobutyrylation of Tropomyosin 3 Lys141: Targeting Histone Deacetylase 3 as a Key Approach.Journal of the American Heart Association · 2025Article
- Review
- P300 regulates histone crotonylation and preimplantation embryo development.Nature communications · 2024Article
- Protein crotonylation: Basic research and clinical diseases.Biochemistry and biophysics reports · 2024Review
- Crotonylation modification and its role in diseases.Frontiers in molecular biosciences · 2024Review
- Research progress on post-translational modification of proteins and cardiovascular diseases.Cell death discovery · 2023Review
- Proteomics analysis of lysine crotonylation and 2-hydroxyisobutyrylation reveals significant features of systemic lupus erythematosus.Clinical rheumatology · 2022Article
- Lysine Crotonylation: An Emerging Player in DNA Damage Response.Biomolecules · 2022Review
- Comprehensive Profiling of Paper Mulberry (International journal of molecular sciences · 2022Article
- Qualitative Proteome-Wide Analysis Reveals the Diverse Functions of Lysine Crotonylation inFrontiers in plant science · 2022Article
- Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2.Cell discovery · 2021Article
- The decrotonylase FoSir5 facilitates mitochondrial metabolic state switching in conidial germination ofeLife · 2021Article
- Protein acetylation in cardiac aging.Journal of molecular and cellular cardiology · 2021Review
- Protein lysine crotonylation: past, present, perspective.Cell death & disease · 2021Review
- Article
- Emerging roles of non-histone protein crotonylation in biomedicine.Cell & bioscience · 2021Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zebrafish embryos are translucent and develop rapidly in individual eggs ex utero; they are widely used as models for embryogenesis and organ development for human diseases and drug discovery. Lysine crotonylation (Kcr) is a type of histone post-translational modifications discovered in 2011. Kcr dynamics are involved in gene expression regulation and acute kidney injury; however, little is known about the effects of Kcr on non-histone proteins. In the present study, we conducted the first proteome-wide profiling of Kcr in zebrafish larvae and identified 557 Kcr sites on 218 proteins, representing the Kcr event in zebrafish. We identified two types of Kcr motifs containing hydrophobic (Leu, Ile, Val) and acidic (Asp and Glu) amino acids near the modified lysine residues. Our results show that both crotonylated proteins and sites of crotonylation were evolutionarily conserved between zebrafish embryos and humans. Specifically, Kcr on ribosomal proteins and myofilament proteins, including myosin, tropomyosin and troponin, were widely enriched. Interestingly, 55 lysine crotonylation sites on myosin were distributed throughout coiled coil regions. Therefore, Kcr may regulate muscle contraction and protein synthesis. Our results provide a foundation for future studies on the effects of lysine crotonylation on aging and heart failure.
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