Evidence map›Paper›PMID 29483600›Full record

ArticleNature nanotechnology2018

Charge splitters and charge transport junctions based on guanine quadruplexes.

Ruojie Sha, Limin Xiang, Chaoren Liu, Alexander Balaeff, Yuqi Zhang, Peng Zhang, Yueqi Li, David N Beratan, Nongjian Tao, Nadrian C Seeman

Abstract read
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In one paragraph

Article in Nature nanotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Electron Holes in G-Quadruplexes: The Role of Adenine Ending Groups.International journal of molecular sciences · 2021
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Why Are DNA and Protein Electron Transfer So Different?Annual review of physical chemistry · 2019
    Review
  12. Hole Hopping Across a Protein-Protein Interface.The journal of physical chemistry. B · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ruojie ShaDepartment of Chemistry, New York University, New York, NY, USA.
Limin XiangBiodesign Center for Biosensors and Bioelectronics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.ORCID 0000-0003-1488-2705
Chaoren LiuDepartments of Chemistry, Duke University, Durham, NC, USA.
Alexander BalaeffDepartments of Chemistry, Duke University, Durham, NC, USA.
Yuqi ZhangDepartments of Chemistry, Duke University, Durham, NC, USA.
Peng ZhangDepartments of Chemistry, Duke University, Durham, NC, USA.
Yueqi LiBiodesign Center for Biosensors and Bioelectronics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
David N BeratanDepartments of Chemistry, Duke University, Durham, NC, USA. david.beratan@duke.edu.ORCID 0000-0003-4758-8676
Nongjian TaoBiodesign Center for Biosensors and Bioelectronics, Biodesign Institute, Arizona State University, Tempe, AZ, USA. njtao@asu.edu.
Nadrian C SeemanDepartment of Chemistry, New York University, New York, NY, USA. ned.seeman@nyu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Self-assembling circuit elements, such as current splitters or combiners at the molecular scale, require the design of building blocks with three or more terminals. A promising material for such building blocks is DNA, wherein multiple strands can self-assemble into multi-ended junctions, and nucleobase stacks can transport charge over long distances. However, nucleobase stacking is often disrupted at junction points, hindering electric charge transport between the two terminals of the junction. Here, we show that a guanine-quadruplex (G4) motif can be used as a connector element for a multi-ended DNA junction. By attaching specific terminal groups to the motif, we demonstrate that charges can enter the structure from one terminal at one end of a three-way G4 motif, and can exit from one of two terminals at the other end with minimal carrier transport attenuation. Moreover, we study four-way G4 junction structures by performing theoretical calculations to assist in the design and optimization of these connectors.

Indexed as

Electric ConductivityG-QuadruplexesCationsDNAGuanineMolecular Dynamics SimulationNanostructuresNanotechnologyCationsDNAGuanine

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.