ArticleScientific reports2018
High motor variability in DYT1 dystonia is associated with impaired visuomotor adaptation.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- A serious game for assessing upper-limb visuomotor adaptation in children with cerebral palsy during reaching tasks in virtual reality.Scientific reports · 2026Article
- A Serious Game for the Assessment of Visuomotor Adaptation Capabilities during Locomotion Tasks Employing an Embodied Avatar in Virtual Reality.Sensors (Basel, Switzerland) · 2023Article
- The dissociable effects of reward on sequential motor behavior.Journal of neurophysiology · 2022Article
- A Critical Investigation of Cerebellar Associative Learning in Isolated Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2022Article
- Impaired Saccade Adaptation in Tremor-Dominant Cervical Dystonia-Evidence for Maladaptive Cerebellum.Cerebellum (London, England) · 2021Article
- Motor learning deficits in cervical dystonia point to defective basal ganglia circuitry.Scientific reports · 2021Article
- The Use of Botulinum Toxin for Treatment of the Dystonias.Handbook of experimental pharmacology · 2021Article
- Article
- Advances in the pathophysiology of adult-onset focal dystonias: recent neurophysiological and neuroimaging evidence.F1000Research · 2020Review
- Sensorimotor Control in Dystonia.Brain sciences · 2019Review
- Methods for measuring swallowing pressure variability using high-resolution manometry.Frontiers in applied mathematics and statistics · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
For the healthy motor control system, an essential regulatory role is maintaining the equilibrium between keeping unwanted motor variability in check whilst allowing informative elements of motor variability. Kinematic studies in children with generalised dystonia (due to mixed aetiologies) show that movements are characterised by increased motor variability. In this study, the mechanisms by which high motor variability may influence movement generation in dystonia were investigated. Reaching movements in the symptomatic arm of 10 patients with DYT1 dystonia and 12 age-matched controls were captured using a robotic manipulandum and features of motor variability were extracted. Given that task-relevant variability and sensorimotor adaptation are related in health, markers of variability were then examined for any co-variance with performance indicators during an error-based learning visuomotor adaptation task. First, we confirmed that motor variability on a trial-by-trial basis was selectively increased in the homogenous and prototypical dystonic disorder DYT1 dystonia. Second, high baseline variability predicted poor performance in the subsequent visuomotor adaptation task offering insight into the rules which appear to govern dystonic motor control. The potential mechanisms behind increased motor variability and its corresponding implications for the rehabilitation of patients with DYT1 dystonia are highlighted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.