ArticleScientific reports2018
Morphological evidence of telocytes in human synovium.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Telocytes in skeletal muscle: Emerging players in homeostasis and repair/regeneration.Histology and histopathology · 2026Review
- First report of telocytes in human ovarian stroma: an ultrastructural and immunohistochemical study.Histochemistry and cell biology · 2025Article
- Morphological characteristics and distribution identification of telocytes in Tibetan sheep testis and epididymis.Scientific reports · 2024Article
- Telocytes: current methods of research, challenges and future perspectives.Cell and tissue research · 2024Review
- Morphological and histochemical identification of telocytes in adult yak epididymis.Scientific reports · 2023Article
- Development and validation of cuproptosis-related genes in synovitis during osteoarthritis progress.Frontiers in immunology · 2023Article
- Article
- Immunohistochemical study on the distribution of telocytes in the knee joint components in a rat osteoarthritis model.Journal of physical therapy science · 2022Article
- Morphologic evidence of telocytes in human thyroid stromal tissue.Journal of cellular and molecular medicine · 2022Article
- Telocytes: An Emerging Component of Stem Cell Niche Microenvironment.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2021Review
- Fibroblast pathology in inflammatory diseases.The Journal of clinical investigation · 2021Review
- MicroRNA-126 Attenuates the Effect of Chemokine CXCL8 on Proliferation, Migration, Apoptosis, and MAPK-Dependent Signaling Activity of Vascular Endothelial Cells Cultured in a Medium with High Glucose Concentration.Bulletin of experimental biology and medicine · 2021Article
- Impairment in the telocyte/CD34Journal of cellular and molecular medicine · 2021Article
- Telocytes/CD34+ Stromal Cells in Pathologically Affected White Adipose Tissue.International journal of molecular sciences · 2020Review
- Telocytes contribute to aging-related modifications in the prostate.Scientific reports · 2020Article
- A Two-Step Immunomagnetic Microbead-Based Method for the Isolation of Human Primary Skin Telocytes/CD34+ Stromal Cells.International journal of molecular sciences · 2020Article
- Morphological evidence for telocytes as stromal cells supporting satellite cell activation in eccentric contraction-induced skeletal muscle injury.Scientific reports · 2019Article
- Expression of toll-like receptors and their regulatory roles in murine cardiac telocytes.Journal of cellular and molecular medicine · 2019Article
- Telocytes constitute a widespread interstitial meshwork in the lamina propria and underlying striated muscle of human tongue.Scientific reports · 2019Article
- Morphological changes of telocytes in camel efferent ductules in response to seasonal variations during the reproductive cycle.Scientific reports · 2019Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A new cell type named telocyte (i.e. cell with distinctive prolongations called telopodes) has recently been identified in the stroma of various organs in humans. However, no study has yet reported the existence of telocytes in the synovial membrane of diarthrodial joints. This work was therefore undertaken to search for telocytes in the normal human synovium using transmission electron microscopy, immunohistochemistry and immunofluorescence. Ultrastructural analyses demonstrated the presence of numerous spindle-shaped telocytes in the whole synovial sublining layer. Synovial telocytes exhibited very long and thin moniliform telopodes and were particularly concentrated at the boundary between the lining and sublining layers and around blood vessels. Light microscopy confirmed the presence of CD34-positive telocytes in the aforementioned locations. Moreover, synovial telocytes coexpressed CD34 and platelet-derived growth factor receptor α. Double immunostaining further allowed to unequivocally differentiate synovial telocytes (CD34-positive/CD31-negative) from vascular endothelial cells (CD34-positive/CD31-positive). The in vitro examination of fibroblast-like synoviocyte primary cultures revealed the coexistence of different cell types, including CD34-positive telocytes projecting typical moniliform telopodes. In conclusion, our work provides the first evidence that telocytes do exist in the human synovium and lays the groundwork for future studies on synovial telocytes in a variety of degenerative and destructive joint diseases.
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