Evidence map›Paper›PMID 29483548›Full record

ArticleNature communications2018

Sculpting nanoparticle dynamics for single-bacteria-level screening and direct binding-efficiency measurement.

Y Z Shi, S Xiong, Y Zhang, L K Chin, Y -Y Chen, J B Zhang, T H Zhang, W Ser, A Larrson, S H Lim and 10 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 168 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 3 countries.

Y Z ShiSchool of Mechanical Engineering, Xi'an Jiaotong University, Xi'an, 710049, China.
S XiongSchool of Electrical and Electronic Engineering, Nanyang Technological University, Singapore, 639798, Singapore. xiongsha@ntu.edu.sg.
Y ZhangSchool of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore, 639798, Singapore.ORCID http://orcid.org/0000-0002-1239-3441
L K ChinSchool of Electrical and Electronic Engineering, Nanyang Technological University, Singapore, 639798, Singapore.
Y -Y ChenSchool of Electrical and Electronic Engineering, Nanyang Technological University, Singapore, 639798, Singapore.
J B ZhangSchool of Electrical and Electronic Engineering, Nanyang Technological University, Singapore, 639798, Singapore.
T H ZhangDepartment of Electrical and Computer Engineering, National University of Singapore, Singapore, 117583, Singapore.
W SerSchool of Electrical and Electronic Engineering, Nanyang Technological University, Singapore, 639798, Singapore.
A LarrsonSchool of Biological Sciences, Nanyang Technological University, Singapore, 639798, Singapore.
S H LimSchool of Biological Sciences, Nanyang Technological University, Singapore, 639798, Singapore.
J H WuSchool of Mechanical Engineering, Xi'an Jiaotong University, Xi'an, 710049, China.
T N ChenSchool of Mechanical Engineering, Xi'an Jiaotong University, Xi'an, 710049, China.
Z C YangNational Key Laboratory of Science and Technology on Micro/Nano Fabrication, Institute of Microelectronics, Peking University, Beijing, 100871, China.
Y L HaoNational Key Laboratory of Science and Technology on Micro/Nano Fabrication, Institute of Microelectronics, Peking University, Beijing, 100871, China.
B LiedbergCentre for Biomimetic Sensor Science, School of Materials Science and Engineering, Nanyang Technological University, Singapore, 639798, Singapore.
P H YapLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 308232, Singapore.
K WangCollege of Biomedical Engineering, Taipei Medical University, Taipei, 11031, Taiwan.
D P TsaiDepartment of Physics, National Taiwan University, Taipei, 10617, Taiwan.
C-W QiuDepartment of Electrical and Computer Engineering, National University of Singapore, Singapore, 117583, Singapore. eleqc@nus.edu.sg.
A Q LiuSchool of Electrical and Electronic Engineering, Nanyang Technological University, Singapore, 639798, Singapore. eaqliu@ntu.edu.sg.
Nanyang Technological University · SGNational University of Singapore · SGPeking University · CNXi'an Jiaotong University · CNNational Taiwan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Particle trapping and binding in optical potential wells provide a versatile platform for various biomedical applications. However, implementation systems to study multi-particle contact interactions in an optical lattice remain rare. By configuring an optofluidic lattice, we demonstrate the precise control of particle interactions and functions such as controlling aggregation and multi-hopping. The mean residence time of a single particle is found considerably reduced from 7 s, as predicted by Kramer's theory, to 0.6 s, owing to the mechanical interactions among aggregated particles. The optofluidic lattice also enables single-bacteria-level screening of biological binding agents such as antibodies through particle-enabled bacteria hopping. The binding efficiency of antibodies could be determined directly, selectively, quantitatively and efficiently. This work enriches the fundamental mechanisms of particle kinetics and offers new possibilities for probing and utilising unprecedented biomolecule interactions at single-bacteria level.

Indexed as

BacteriaKineticsMicrofluidic Analytical TechniquesNanoparticles

Identifiers

PMID29483548
PMCPMC5827716
OpenAlexW2800654689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.