ReviewBioscience reports2018
Maternal obesity increases the risk of metabolic disease and impacts renal health in offspring.
Review in Bioscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 74 citations in OpenAlex.
- Gonadotropin response to insulin and lipid infusion reproduces the reprometabolic syndrome of obesity in eumenorrheic lean women: a randomized crossover trial.Fertility and sterility · 2021Trial
- Exploring the associations of overweight and obesity with pregnancy outcomes in type 1 and type 2 diabetes: An Australian retrospective cohort study.Journal of diabetes investigation · 2026Article
- Sex differences in the developmental programming of cardiovascular and renal risk across the lifespan.American journal of physiology. Renal physiology · 2026Review
- Maternal obesity induces macrophage to myofibroblast transition in kidneys of male offspring through a pathway driven by 20-hydroxyeicosatetraenoic acid.Nature communications · 2026Article
- Lysine-specific histone demethylase 1a regulates nephron development and long-term transcriptional programming.JCI insight · 2026Article
- Preconception Weight Loss to Prevent Childhood Obesity: Current Evidence and Research Gaps.Current obesity reports · 2026Review
- Maternal exercise is associated with a shift in adiposity distribution and improved markers of adipose health in offspring in mice.Pregnancy (Hoboken, N.J.) · 2026Article
- Immune dysregulation linking pre-pregnancy obesity to gestational diabetes mellitus.Frontiers in immunology · 2026Review
- Maternal obesity promotes impaired renal autophagic process and kidney injury in male offspring.International journal of obesity (2005) · 2025Article
- Parental obesity predisposes male and female offspring to exacerbated cardiac dysfunction and increased mortality after myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2025Article
- Diet and Disease Development: Present and Future.Nutrients · 2024Article
- Genetic Ablation of C/EBPα-p300 Pathway Blocks Development of Obese Pregnancy Associated Liver Disorders in Offspring.Cellular and molecular gastroenterology and hepatology · 2024Article
- Effects of Gestational and Lactational Lead Exposure and High Fat Diet Feeding on Cerebellar Development of Postnatal Rat Offspring.Nutrients · 2023Article
- The contributions of parental lactation on offspring development: It's not udder nonsense!Hormones and behavior · 2023Review
- The effect of source of protein fed during pregnancy and lactation on the development of characteristics of metabolic syndrome in male offspring of obese Wistar rats.Journal of nutritional science · 2023Article
- Maternal obesity alters offspring liver and skeletal muscle metabolism in early post-puberty despite maintaining a normal post-weaning dietary lifestyle.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Cord blood metabolomics reveals gestational metabolic disorder associated with anti-thyroid peroxidase antibodies positivity.BMC pregnancy and childbirth · 2022Article
- Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment.International journal of environmental research and public health · 2022Review
- Maternal Western diet exposure increases periportal fibrosis beginning in utero in nonhuman primate offspring.JCI insight · 2021Article
- Periodontitis and Gestational Diabetes Mellitus: A Potential Inflammatory Vicious Cycle.International journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity, together with insulin resistance, promotes multiple metabolic abnormalities and is strongly associated with an increased risk of chronic disease including type 2 diabetes (T2D), hypertension, cardiovascular disease, non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD). The incidence of obesity continues to rise in astronomical proportions throughout the world and affects all the different stages of the lifespan. Importantly, the proportion of women of reproductive age who are overweight or obese is increasing at an alarming rate and has potential ramifications for offspring health and disease risk. Evidence suggests a strong link between the intrauterine environment and disease programming. The current review will describe the importance of the intrauterine environment in the development of metabolic disease, including kidney disease. It will detail the known mechanisms of fetal programming, including the role of epigenetic modulation. The evidence for the role of maternal obesity in the developmental programming of CKD is derived mostly from our rodent models which will be described. The clinical implication of such findings will also be discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.