ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2018
Brain neuroreceptor density and personality traits: towards dimensional biomarkers for psychiatric disorders.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- The Role of Willpower in Major Depressive Disorder: An fMRI Study.Brain and behavior · 2025Article
- Article
- In Vivo Serotonin 5-HT2A Receptor Availability and Its Relationship with Aggression Traits in Healthy Individuals: A Positron Emission Tomography Study with C-11 MDL100907.International journal of molecular sciences · 2023Article
- Expression and co-expression of serotonin and dopamine transporters in social anxiety disorder: a multitracer positron emission tomography study.Molecular psychiatry · 2021Article
- Review
- Association between GPx-1 polymorphisms and personality traits in healthy Chinese-Han subjects.Brain and behavior · 2020Article
- Multiscale neurobiological correlates of human neuroticism.Human brain mapping · 2020Article
- Higher- and lower-order personality traits and cluster subtypes in social anxiety disorder.PloS one · 2020Article
- Diversity in action: exchange of perspectives and reflections on taxonomies of individual differences.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Opinion on monoaminergic contributions to traits and temperament.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Taxonomies of psychological individual differences: biological perspectives on millennia-long challenges.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Functionality versus dimensionality in psychological taxonomies, and a puzzle of emotional valence.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Trait impulsivity is not related to post-commissural putamen volumes: A replication study in healthy men.PloS one · 2018Article
- The relationship between personality traits and Alzheimer's disease: a narrative review.Frontiers in neurologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Positron emission tomography has, for 30 years, been used in numerous case-control studies searching for hypothesized differences in the density of neuroreceptor or transporter proteins in psychiatric disorders such as schizophrenia and depression. In most cases, the results have not been conclusive. One reason could be the sizeable interindividual variability in biochemical markers, which in twin studies have shown to emanate from both environmental and genetic factors, leading to low statistical power for the detection of group effects. On the other hand, the same interindividual variability has served as an opportunity for correlative studies on the biological underpinning of behaviour. Using this approach, a series of studies has linked markers for the dopamine and serotonin system to personality traits associated with psychiatric conditions. Based on increasing evidence for the view that many psychopathological states represent extremes of a continuum rather than distinct categories, this research strategy may lead to new biological insights about the vulnerability to and pathophysiology of major psychiatric disorders.This article is part of the theme issue 'Diverse perspectives on diversity: multi-disciplinary approaches to taxonomies of individual differences'.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.