Evidence map›Paper›PMID 29483294›Full record

ArticleInfection and immunity2018

Type IV Pili Promote Clostridium difficile Adherence and Persistence in a Mouse Model of Infection.

Robert W McKee, Naira Aleksanyan, Elizabeth M Garrett, Rita Tamayo

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 103 citations in OpenAlex.

  1. A programmed reset mechanism primesScience advances · 2026
    Article
  2. Review
  3. Clostridioides difficile pathogenesis and control.Nature reviews. Microbiology · 2026
    Review
  4. Article
  5. Dissecting the role of flagellar subunits inJournal of bacteriology · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. The current riboswitch landscape inMicrobiology (Reading, England) · 2024
    Review
  13. Article
  14. Article
  15. mSphere · 2024
    Article
  16. Review
  17. Biofilm Formation ofMicroorganisms · 2023
    Review
  18. Article
  19. Article
  20. Microbiology (Reading, England) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Robert W McKeeDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Naira AleksanyanDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Elizabeth M GarrettDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Rita TamayoDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA Rita_tamayo@med.unc.edu.ORCID https://orcid.org/0000-0002-3745-3316
University of North Carolina at Chapel Hill · US

Funding

Regulation of Clostridium difficile Colonization FactorsR01AI107029 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TAMAYO, RITA · 2013 to 2022
$3.9M
Phase variation of virulence factors in Clostridioides difficileR37AI107029 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RITA TAMAYO · 2025 to 2026
$1.0M
NIAID NIH HHS R01 AI107029NIAID NIH HHS R37 AI107029
6 · The paper itself

Abstract

Cyclic diguanylate (c-di-GMP) is a second messenger that regulates the transition from motile to sessile lifestyles in numerous bacteria and controls virulence factor production in a variety of pathogens. In

Indexed as

Immune Adherence ReactionAdhesins, BacterialAnimalsClostridioides difficileClostridium InfectionsMiceModels, AnimalVirulence FactorsAdhesins, BacterialVirulence Factorsadhesinc-di-GMPClostridioidesClostridioides difficilecolonizationriboswitchTcdRtype IV pili

Identifiers

PMID29483294
PMCPMC5913833
OpenAlexW2788458738

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.