ArticleProceedings of the National Academy of Sciences of the United States of America2018
d-Sedoheptulose-7-phosphate is a common precursor for the heptoses of septacidin and hygromycin B.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Article
- Deciphering hygromycin B biosynthetic pathway and D-optimal design for production optimization.World journal of microbiology & biotechnology · 2025Article
- Initiation, Propagation, and Termination in the Chemistry of Radical SAM Enzymes.Biochemistry · 2024Review
- Microbial synthesis of sedoheptulose from glucose by metabolically engineered Corynebacterium glutamicum.Microbial cell factories · 2024Article
- Characterization of the ADP-β-D-manno-heptose biosynthetic enzymes from two pathogenic Vibrio strains.Applied microbiology and biotechnology · 2024Article
- A Bittersweet Kiss of Gram-Negative Bacteria: The Role of ADP-Heptose in the Pathogenesis of Infection.Microorganisms · 2023Review
- Insights into the biosynthesis of septacidin l-heptosamine moiety unveils a VOC family sugar epimerase.Acta pharmaceutica Sinica. B · 2023Article
- Synthetic Optimizations for Gram-Scale Preparation of 1-Molecules (Basel, Switzerland) · 2022Article
- Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC.The Biochemical journal · 2022Article
- A conservative distribution of tridomain NDP-heptose synthetases in actinobacteria.Science China. Life sciences · 2022Article
- Discovery of novel septacidin congeners from a high yield heterologous expression strain Streptomyces albus 1597.The Journal of antibiotics · 2022Article
- HygY Is a Twitch Radical SAM Epimerase with Latent Dehydrogenase Activity Revealed upon Mutation of a Single Cysteine Residue.Journal of the American Chemical Society · 2021Article
- Indolyl Septanoside Synthesis for In Vivo Screening of Bacterial Septanoside Hydrolases.International journal of molecular sciences · 2021Article
- Review
- ADP-heptose: a bacterial PAMP detected by the host sensor ALPK1.Cellular and molecular life sciences : CMLS · 2021Review
- Comparison of Antibiotic Resistance Mechanisms in Antibiotic-Producing and Pathogenic Bacteria.Molecules (Basel, Switzerland) · 2019Review
- Genetic platforms for heterologous expression of microbial natural products.Natural product reports · 2019Review
- ADP heptose, a novel pathogen-associated molecular pattern identified inFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Article
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Seven-carbon-chain-containing sugars exist in several groups of important bacterial natural products. Septacidin represents a group of l-heptopyranoses containing nucleoside antibiotics with antitumor, antifungal, and pain-relief activities. Hygromycin B, an aminoglycoside anthelmintic agent used in swine and poultry farming, represents a group of d-heptopyranoses-containing antibiotics. To date, very little is known about the biosynthesis of these compounds. Here we sequenced the genome of the septacidin producer and identified the septacidin gene cluster by heterologous expression. After determining the boundaries of the septacidin gene cluster, we studied septacidin biosynthesis by in vivo and in vitro experiments and discovered that SepB, SepL, and SepC can convert d-sedoheptulose-7-phosphate (S-7-P) to ADP-l-
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