Evidence map›Paper›PMID 29483217›Full record

ArticleMolecular cancer therapeutics2018

The Unfolded Protein Response: A Novel Therapeutic Target for Poor Prognostic

Nicholas Forsythe, Alaa Refaat, Arman Javadi, Hajrah Khawaja, Jessica-Anne Weir, Heba Emam, Wendy L Allen, Frank Burkamp, Vlad Popovici, Puthen V Jithesh and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Role of HDAC6 and Its Selective Inhibitors in Gastrointestinal Cancer.Frontiers in cell and developmental biology · 2021
    Review
  11. Article
  12. ERK is a Pivotal Player of Chemo-Immune-Resistance in Cancer.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 5 countries.

Nicholas Forsythe *Drug Resistance Group, Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, United Kingdom.
Alaa Refaat *Drug Resistance Group, Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, United Kingdom.ORCID 0000-0002-7821-2500
Arman JavadiDrug Resistance Group, Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, United Kingdom.
Hajrah KhawajaDrug Resistance Group, Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, United Kingdom.
Jessica-Anne WeirDrug Resistance Group, Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, United Kingdom.
Heba EmamDrug Resistance Group, Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, United Kingdom.
Wendy L AllenDrug Resistance Group, Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, United Kingdom.ORCID 0000-0003-0732-4123
Frank BurkampAlmac Discovery Laboratories, Centre for Precision Therapeutics, Belfast, United Kingdom.
Vlad PopoviciResearch Centre for Toxic Compounds in the Environment, Faculty of Science, Masarykova Univerzita, Czech Republic.
Puthen V JitheshDivision of Biomedical Informatics, Sidra Medical and Research Center, Education City North Campus, Doha, Qatar.ORCID 0000-0001-7747-0930
Claudio IsellaDepartment of Oncology, University of Torino School of Medicine, Candiolo, Torino, Italy.
Melissa J LabonteDrug Resistance Group, Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, United Kingdom.
Ian G MillsDrug Resistance Group, Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, United Kingdom.ORCID 0000-0001-5347-5083
Patrick G JohnstonDrug Resistance Group, Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, United Kingdom.
Sandra Van SchaeybroeckDrug Resistance Group, Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, United Kingdom. s.vanschaeybroeck@qub.ac.uk.
Queen's University Belfast · GBPrecision Therapeutics (United States) · USRECETOX · CZSidra Medical and Research Center · QATorino e-district · IT

Funding

Cancer Research UK 13172Cancer Research UK 24744Cancer Research UK C13749/A13172Cancer Research UK C212/A13721
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

MutationAntineoplastic AgentsApoptosisBiomarkers, TumorCell Line, TumorCell SurvivalColorectal NeoplasmsEndoplasmic Reticulum Chaperone BiPEndoplasmic Reticulum StressHeat-Shock ProteinsHumansHydroxamic AcidsMAP Kinase Signaling SystemModels, BiologicalOligopeptidesPrognosisAntineoplastic AgentsBiomarkers, TumorcarfilzomibDDIT3 protein, humanEndoplasmic Reticulum Chaperone BiPHeat-Shock ProteinsHSPA5 protein, humanHydroxamic AcidsOligopeptidesProtein Kinase InhibitorsProto-Oncogene Proteins B-rafPyrimidinesricolinostatTranscription Factor CHOP

Identifiers

PMID29483217
PMCPMC5985931
OpenAlexW2788709098

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.