Evidence map›Paper›PMID 29483189›Full record

ArticleThe Journal of biological chemistry2018

Deletion of the neural tube defect-associated gene

Joshua D Bryant, Shannon R Sweeney, Enrique Sentandreu, Minhye Shin, Hélène Ipas, Blerta Xhemalce, Jessica Momb, Stefano Tiziani, Dean R Appling

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Folate Production byJournal of microbiology and biotechnology · 2025
    Article
  4. Brain development and bioenergetic changes.Neurobiology of disease · 2024
    Review
  5. Article
  6. Maternal metabolism influences neural tube closure.Trends in endocrinology and metabolism: TEM · 2023
    Review
  7. Article
  8. Article
  9. Implication of folate deficiency in CYP2U1 loss of function.The Journal of experimental medicine · 2021
    Article
  10. Article
  11. Article
  12. Article
  13. Formate metabolism in health and disease.Molecular metabolism · 2020
    Review
  14. Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Joshua D BryantFrom the Departments of Molecular Biosciences and.
Shannon R SweeneyNutritional Sciences and the Dell Pediatric Research Institute, The University of Texas at Austin, Austin, Texas 78712.
Enrique SentandreuNutritional Sciences and the Dell Pediatric Research Institute, The University of Texas at Austin, Austin, Texas 78712.
Minhye ShinFrom the Departments of Molecular Biosciences and.
Hélène IpasFrom the Departments of Molecular Biosciences and.
Blerta XhemalceFrom the Departments of Molecular Biosciences and.
Jessica MombFrom the Departments of Molecular Biosciences and.
Stefano TizianiNutritional Sciences and the Dell Pediatric Research Institute, The University of Texas at Austin, Austin, Texas 78712.
Dean R ApplingFrom the Departments of Molecular Biosciences and dappling@austin.utexas.edu.
The University of Texas at Austin · US

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Robin Jean Leach · 1991 to 2026
$59.1M
INTERVENTION STRATEGIES FOR NON-FOLATE RESPONSIVE NEURAL TUBE DEFECTSR01HD083809 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI FINNELL, RICHARD H. · 2016 to 2024
$5.1M
Mammalian Mitochondrial One-Carbon MetabolismR01GM086856 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI APPLING, DEAN R · 2009 to 2010
$627k
Mechanisms of mitochondrial folate metabolism in neural tube closureF32HD074428 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI MOMB, JESSICA E. · 2012 to 2014
$163k
NCI NIH HHS P30 CA054174NICHD NIH HHS F32 HD074428NICHD NIH HHS R01 HD083809NIGMS NIH HHS R01 GM086856
6 · The paper itself

Abstract

One-carbon (1C) metabolism is a universal folate-dependent pathway essential for

Indexed as

Energy MetabolismGene DeletionGene Expression Regulation, DevelopmentalMetabolic Networks and PathwaysAminohydrolasesAnimalsCells, CulturedEmbryo, MammalianFolic AcidFormatesFormate-Tetrahydrofolate LigaseGlycolysisMetabolomeMethylenetetrahydrofolate Dehydrogenase (NADP)MiceMice, Inbred C57BLAminohydrolasesFolic AcidFormatesFormate-Tetrahydrofolate Ligaseformic acidformyl-methenyl-methylenetetrahydrofolate synthetaseMethylenetetrahydrofolate Dehydrogenase (NADP)Multienzyme Complexesembryoenergy metabolismfolatemetabolomicsmitochondrial metabolismneural tube closure

Identifiers

PMID29483189
PMCPMC5912453
OpenAlexW2792552361

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.