Evidence map›Paper›PMID 29483167›Full record

ArticleJournal of bacteriology2018

Stress Suppressor Screening Leads to Detection of Regulation of Cyclic di-AMP Homeostasis by a Trk Family Effector Protein in Streptococcus pneumoniae.

Tiffany M Zarrella, Dennis W Metzger, Guangchun Bai

Open access · bronzeAbstract read
In one paragraph

Article in Journal of bacteriology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 52 citations in OpenAlex.

  1. Regulation of potassium homeostasis inFrontiers in microbiology · 2026
    Article
  2. Clinical microbiology reviews · 2025
    Review
  3. Article
  4. TrkA ofMicrobiology (Reading, England) · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Bacterial cell volume regulation and the importance of cyclic di-AMP.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  10. Loss of Pde1 function acts as an evolutionary gateway to penicillin resistance inProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  11. Review
  12. IPA-3: An Inhibitor of Diadenylate Cyclase ofAntibiotics (Basel, Switzerland) · 2022
    Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. c-di-AMP, a likely master regulator of bacterial KProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tiffany M ZarrellaDepartment of Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA.
Dennis W MetzgerDepartment of Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA.
Guangchun BaiDepartment of Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA baig@mail.amc.edu.
Albany Medical Center Hospital · US

Funding

Pneumonia BiologyR35HL135756 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MIZGERD, JOSEPH P · 2017 to 2023
$6.6M
Otitis Media-associated pneumococcal genesR01DC006917 · NIDCD · ALBANY MEDICAL COLLEGE · PI METZGER, DENNIS W, YAN, HONGGAO · 2004 to 2014
$4.1M
Macrophage protection in pneumococcal pneumoniaR56AI122763 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MIZGERD, JOSEPH P · 2016 to 2016
$640k
NHLBI NIH HHS R35 HL135756NIAID NIH HHS R56 AI122763NIDCD NIH HHS R01 DC006917
6 · The paper itself

Abstract

Cyclic di-AMP (c-di-AMP) is a newly discovered bacterial second messenger. However, regulation of c-di-AMP homeostasis is poorly understood. In

Indexed as

Gene Expression Regulation, BacterialBacterial ProteinsCyclic AMPHomeostasisMultigene FamilyPhosphoric Diester HydrolasesPhosphorus-Oxygen LyasesPotassiumSecond Messenger SystemsStreptococcus pneumoniaeBacterial ProteinsCyclic AMPPhosphoric Diester HydrolasesPhosphorus-Oxygen LyasesPotassiumCabPCdaAc-di-AMPStreptococcus pneumoniaestress responseTrkH

Identifiers

PMID29483167
PMCPMC5971481
OpenAlexW2793239843

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.