Evidence map›Paper›PMID 29483153›Full record

ArticleGenes & development2018

Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers.

Ken Takai, Allison P Drain, Devon A Lawson, Laurie E Littlepage, Marcela Karpuj, Kai Kessenbrock, Annie Le, Kenichi Inoue, Valerie M Weaver, Zena Werb

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.

  1. Physical Forces in Glioblastoma Migration: A Systematic Review.International journal of molecular sciences · 2022
    Pooled it
  2. Article
  3. Article
  4. Review
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  8. Article
  9. Extracellular Matrix ModulationCurrent medicinal chemistry · 2025
    Article
  10. Review
  11. Article
  12. Review
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  14. Article
  15. Friend or foe? The elusive role of hepatic stellate cells in liver cancer.Nature reviews. Gastroenterology & hepatology · 2023
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Ken TakaiDepartment of Anatomy, University of California at San Francisco, San Francisco, California 94143, USA.
Allison P DrainDepartment of Surgery, Center for Bioengineering and Tissue Regeneration, University of California at San Francisco, San Francisco, California 94143, USA.
Devon A LawsonDepartment of Anatomy, University of California at San Francisco, San Francisco, California 94143, USA.
Laurie E LittlepageDepartment of Anatomy, University of California at San Francisco, San Francisco, California 94143, USA.
Marcela KarpujDepartment of Anatomy, University of California at San Francisco, San Francisco, California 94143, USA.
Kai KessenbrockDepartment of Anatomy, University of California at San Francisco, San Francisco, California 94143, USA.
Annie LeDepartment of Anatomy, University of California at San Francisco, San Francisco, California 94143, USA.
Kenichi InoueDivision of Breast Oncology, Saitama Cancer Center, Saitama 362-0806, Japan.
Valerie M WeaverDepartment of Surgery, Center for Bioengineering and Tissue Regeneration, University of California at San Francisco, San Francisco, California 94143, USA.
Zena WerbDepartment of Anatomy, University of California at San Francisco, San Francisco, California 94143, USA.
University of California, San Francisco · USSaitama Cancer Center · JP

Funding

Molecular and Cellular Mechanisms in CancerT32CA108462 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOGA, ANDREI · 2004 to 2024
$10.4M
Project 3: Physical and Metabolic Constraints of Cancer Cell InvasionU54CA210184 · NCI · CORNELL UNIVERSITY · PI SCHAFFER, CHRIS B · 2016 to 2020
$10.2M
Role of Metalloproteinases in Mammary Gland RemodelingR01CA057621 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WERB, ZENA · 1993 to 2017
$9.0M
Tension-Stat3-miR-mediated metastasisR01CA192914 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEEWALDT, VICTORIA L., WEAVER, VALERIE MARIE · 2015 to 2019
$2.9M
Tissue Tension, RANK and Breast Cancer RiskR01CA222508 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HWANG, E.SHELLEY, WEAVER, VALERIE MARIE · 2018 to 2022
$2.8M
Proteolytic regulation of Wnt signaling in breast cancer stem cellsR00CA181490 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI KESSENBROCK, KAI · 2016 to 2018
$730k
Single-cell analysis of intratumor heterogeneity in metastasisK22CA190511 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LAWSON, DEVON A. · 2016 to 2018
$486k
Proteolytic regulation of Wnt signaling in breast cancer stem cellsK99CA181490 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KESSENBROCK, KAI · 2014 to 2015
$268k
NCI NIH HHS K22 CA190511NCI NIH HHS K99 CA181490NCI NIH HHS R00 CA181490NCI NIH HHS R01 CA057621NCI NIH HHS R01 CA192914NCI NIH HHS R01 CA222508NCI NIH HHS T32 CA108462NCI NIH HHS U54 CA210184
6 · The paper itself

Abstract

The discoidin domain receptor 1 (DDR1) is overexpressed in breast carcinoma cells. Low DDR1 expression is associated with worse relapse-free survival, reflecting its controversial role in cancer progression. We detected DDR1 on luminal cells but not on myoepithelial cells of DDR1

Indexed as

AnimalsBreast NeoplasmsCell HypoxiaDiscoidin Domain Receptor 1Disease-Free SurvivalEpithelial CellsFemaleFibrosisHypoxia-Inducible Factor 1, alpha SubunitLung NeoplasmsMammary Neoplasms, ExperimentalMiceDDR1 protein, humanDdr1 protein, mouseDiscoidin Domain Receptor 1Hif1a protein, mouseHypoxia-Inducible Factor 1, alpha Subunitbasal-like phenotypebreast cancerDDR1mammary developmentnecrosis/hypoxia

Identifiers

PMID29483153
PMCPMC5859966
OpenAlexW2789230807

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.