Evidence map›Paper›PMID 29483143›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018

Phase I Study of LY2940680, a Smo Antagonist, in Patients with Advanced Cancer Including Treatment-Naïve and Previously Treated Basal Cell Carcinoma.

Johanna Bendell, Valerie Andre, Alan Ho, Ragini Kudchadkar, Michael Migden, Jeffrey Infante, Ramon V Tiu, Celine Pitou, Trevor Tucker, Les Brail and 1 more

Open access · bronzeAbstract readClinical Trial, Phase IMulticenter Study
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 68 citations in OpenAlex.

  1. Review
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  5. Targeting Fibrosis: From Molecular Mechanisms to Advanced Therapies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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  11. Current Status of Hedgehog Signaling Inhibitors.Current topics in medicinal chemistry · 2024
    Review
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  17. Eradicating the tumor "seeds": nanomedicines-based therapies against cancer stem cells.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 2 countries.

Johanna BendellSarah Cannon Research Institute/Tennessee Oncology, Nashville, Tennessee. jbendell@tnonc.com.
Valerie AndreEli Lilly and Company, Erl Wood, United Kingdom.
Alan HoMemorial Sloan Kettering Cancer Center, New York, New York.
Ragini KudchadkarEmory Winship Cancer Institute, Atlanta, Atlanta, GA.
Michael MigdenUniversity of Texas, MD Anderson Cancer Center, Houston, Texas.
Jeffrey InfanteSarah Cannon Research Institute/Tennessee Oncology, Nashville, Tennessee.
Ramon V TiuEli Lilly and Company, Indianapolis, Indiana.
Celine PitouEli Lilly and Company, Erl Wood, United Kingdom.
Trevor TuckerIgnyta, Inc., San Diego, California.
Les BrailInfinity Pharmaceuticals, Cambridge, Massachusetts.
Daniel Von HoffTranslational Genomics Research Institute, Phoenix, Arizona.
Eli Lilly (United Kingdom) · GBTennessee Oncology · USEli Lilly (United States) · USInfinity Pharmaceuticals (United States) · USKettering University · USPiedmont Cancer Institute · USThe University of Texas MD Anderson Cancer Center · USTranslational Genomics Research Institute · USViaCyte (United States) · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Center for Clinical and Translational Sciences (CCTS)UL1TR000371 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$13.4M
NCATS NIH HHS UL1 TR000371NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Molecular Targeted TherapyAdultAgedAged, 80 and overAntineoplastic AgentsBasal Cell CarcinomaFemaleHumansKaplan-Meier EstimateMaleMiddle AgedNeoplasm GradingNeoplasm MetastasisNeoplasm StagingPhthalazinesRetreatmentAntineoplastic AgentsLY2940680PhthalazinesSmoothened ReceptorSMO protein, human

Identifiers

PMID29483143
PMCPMC6422158
OpenAlexW2792568261

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.