ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018
STAT5A/B Blockade Sensitizes Prostate Cancer to Radiation through Inhibition of RAD51 and DNA Repair.
Abstract read
In one paragraph
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 9% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Bridging Radiotherapy to Immunotherapy: The IFN-JAK-STAT Axis.International journal of molecular sciences · 2021Pooled it
- Relevance of humanized three-dimensional tumor tissue models: a descriptive systematic literature review.Cellular and molecular life sciences : CMLS · 2020Pooled it
- STAT5A-RNF8 signaling regulates homologous recombination repair and cisplatin responsiveness in cervical cancer.Neoplasia (New York, N.Y.) · 2026Article
- TRIM21-mediated ubiquitination of PARP1 regulated by the PI3K/AKT-STAT5A axis suppresses small cell lung cancer.Nature communications · 2026Article
- Review
- Article
- Dual ENPP1/ATM depletion blunts DNA damage repair boosting radioimmune efficacy to abrogate triple-negative breast cancer.Signal transduction and targeted therapy · 2025Article
- The Dual Role of RBBP7 in Esophageal Squamous Cell Carcinoma: Cell Context-Dependent Impacts on Proliferation and Radiosensitivity.OncoTargets and therapy · 2025Article
- METTL3-mediated NOncogene · 2024Article
- Stat5 induces androgen receptor (Science advances · 2024Article
- Targeting the STAT5A/IDO1 axis overcomes radioresistance and reverses the immunosuppressive tumor microenvironment in NSCLC.International journal of oncology · 2023Article
- SPP1 promotes radiation resistance through JAK2/STAT3 pathway in esophageal carcinoma.Cancer medicine · 2022Article
- The Influence of the Pretreatment Immune State on Response to Radiation Therapy in High-Risk Prostate Cancer: A Validation Study From NRG/RTOG 0521.International journal of radiation oncology, biology, physics · 2022Article
- Article
- In-depth analysis of the expression and functions of signal transducers and activators of transcription in human ovarian cancer.Frontiers in oncology · 2022Article
- miR-1247-3p targets STAT5A to inhibit lung adenocarcinoma cell migration and chemotherapy resistance.Journal of Cancer · 2022Article
- Construction and validation of a novel aging-related gene signature and prognostic nomogram for predicting the overall survival in ovarian cancer.Cancer medicine · 2021Article
- CTBP1 strengthens the cisplatin resistance of gastric cancer cells by upregulating RAD51 expression.Oncology letters · 2021Article
- Overexpression of HMGA1 confers radioresistance by transactivating RAD51 in cholangiocarcinoma.Cell death discovery · 2021Article
- Impact of STAT Proteins in Tumor Progress and Therapy Resistance in Advanced and Metastasized Prostate Cancer.Cancers · 2021Review
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Cristina Maranto *Department of Pathology, Prostate Cancer Center of Excellence at Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
Vindhya Udhane *Department of Pathology, Prostate Cancer Center of Excellence at Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
David T HoangDepartment of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
Lei GuDepartment of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
Vitali AlexeevDepartment of Dermatology, Thomas Jefferson University Medical College, Philadelphia, Pennsylvania.
Kareem MalasDepartment of Pathology, Prostate Cancer Center of Excellence at Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
Karmel CardenasDepartment of Pathology, Prostate Cancer Center of Excellence at Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
Jonathan R BrodyDepartment of Surgery, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
Ulrich RodeckDepartment of Dermatology, Thomas Jefferson University Medical College, Philadelphia, Pennsylvania.
Carmen BergomDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Ken A IczkowskiDepartment of Pathology, Prostate Cancer Center of Excellence at Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
Ken JacobsohnDepartment of Urology, Prostate Cancer Center of Excellence at Medical College of Wisconsin, Milwaukee, Wisconsin.
William SeeDepartment of Urology, Prostate Cancer Center of Excellence at Medical College of Wisconsin, Milwaukee, Wisconsin.
Sara M SchmittDepartment of Pathology, Prostate Cancer Center of Excellence at Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
Marja T NevalainenDepartment of Pathology, Prostate Cancer Center of Excellence at Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin. mnevalainen@mcw.edu.
Medical College of Wisconsin · USSidney Kimmel Cancer Center · USThomas Jefferson University · US
Funding
Stat5 in Progression of Prostate CancerR01CA113580 · NCI · THOMAS JEFFERSON UNIVERSITY · PI NEVALAINEN, MARJA T · 2006 to 2015
$2.7MTargeting HuR to improve a synthetic lethal therapy for pancreatic cancerR01CA212600 · NCI · THOMAS JEFFERSON UNIVERSITY · PI BRODY, JONATHAN · 2017 to 2021
$1.9MRegulation of Keratinocyte Survival and DeathR01CA081008 · NCI · THOMAS JEFFERSON UNIVERSITY · PI RODECK, ULRICH · 1998 to 2006
$1.7MClinical and Translational Science AwardKL2TR000056 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI SHAKER, REZA NONE · 2012 to 2015
$609kMonoclonal Antibody-based Prodrugs - Novel Tools for Cancer TherapyR21CA135216 · NCI · THOMAS JEFFERSON UNIVERSITY · PI RODECK, ULRICH, WILLIAMS, JOHN CHARLES · 2010 to 2011
$392kNovel Strategy to Sensitize Prostate Cancer Cells to RadiationR21CA178755 · NCI · THOMAS JEFFERSON UNIVERSITY · PI NEVALAINEN, MARJA T · 2013 to 2014
$365kStat5 acts independently of androgen receptor to drive advanced prostate cancerF31CA180626 · NCI · THOMAS JEFFERSON UNIVERSITY · PI HOANG, DAVID TIMOTHY · 2013 to 2015
$132kNCATS NIH HHS KL2 TR000056NCI NIH HHS F31 CA180626NCI NIH HHS R01 CA081008NCI NIH HHS R01 CA113580NCI NIH HHS R01 CA212600NCI NIH HHS R21 CA135216NCI NIH HHS R21 CA178755
Abstract
PubMed holds no abstract for this paper.
Indexed as
DNA RepairAnimalsApoptosisCell Line, TumorDisease Models, AnimalGastric MucosaGene ExpressionHumansIntestinal MucosaMaleMiceNeoplasm GradingNeoplasm StagingProstatic NeoplasmsRad51 RecombinaseRadiation, IonizingRad51 RecombinaseRNA, Small InterferingSTAT5 Transcription Factor
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.