Evidence map›Paper›PMID 29483122›Full record

ArticleAntimicrobial agents and chemotherapy2018

Aminomethyl Spectinomycins as Therapeutics for Drug-Resistant Gonorrhea and Chlamydia Coinfections.

Michelle M Butler, Samanthi L Waidyarachchi, Kristie L Connolly, Ann E Jerse, Weirui Chai, Richard E Lee, Stephan A Kohlhoff, Dean L Shinabarger, Terry L Bowlin

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Repurposing epetraborole to combatAntimicrobial agents and chemotherapy · 2026
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  7. Review
  8. Repurposing FDA-approved sulphonamide carbonic anhydrase inhibitors for treatment ofJournal of enzyme inhibition and medicinal chemistry · 2022
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. The frontiers of addressing antibiotic resistance in Neisseria gonorrhoeae.Translational research : the journal of laboratory and clinical medicine · 2020
    Review
  17. Article
  18. Review
  19. Repurposing salicylamide for combating multidrug-resistantAntimicrobial agents and chemotherapy · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Michelle M ButlerMicrobiotix, Inc., Worcester, Massachusetts, USA mbutler@microbiotix.com.
Samanthi L WaidyarachchiDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Kristie L ConnollyUniformed Services University, Bethesda, Maryland, USA.
Ann E JerseUniformed Services University, Bethesda, Maryland, USA.
Weirui ChaiDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Richard E LeeDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Stephan A KohlhoffSUNY Downstate Medical Center, Brooklyn, New York, USA.
Dean L ShinabargerMicromyx LLC, Kalamazoo, Michigan, USA.
Terry L BowlinMicrobiotix, Inc., Worcester, Massachusetts, USA.
St. Jude Children's Research Hospital · USMicrobiotix (United States) · USUniformed Services University of the Health Sciences · USSUNY Downstate Health Sciences University · US

Funding

Development of Aminospectinomycins for BiodefenseR01AI111449 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI LEE, RICHARD E. · 2014 to 2018
$3.5M
NIAID NIH HHS R01 AI111449
6 · The paper itself

Abstract

Bacterial sexually transmitted infections are widespread and common, with

Indexed as

AnimalsAnti-Bacterial AgentsAzithromycinCeftriaxoneChlamydia InfectionsChlamydia trachomatisCoinfectionDrug Resistance, Multiple, BacterialFemaleGentamicinsGonorrheaHumansMiceMice, Inbred BALB CMicrobial Sensitivity TestsNeisseria gonorrhoeaeAnti-Bacterial AgentsAzithromycinCeftriaxoneGentamicinsSpectinomycinaminomethyl spectinomycinsantibacterialchlamydiagonorrhea

Identifiers

PMID29483122
PMCPMC5923137
OpenAlexW2792262995

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.