Evidence map›Paper›PMID 29483073›Full record

ArticleCancer prevention research (Philadelphia, Pa.)2018

The Combined Association of Modifiable Risk Factors with Breast Cancer Risk in the Women's Health Initiative.

Rhonda Arthur, Sylvia Wassertheil-Smoller, JoAnn E Manson, Juhua Luo, Linda Snetselaar, Theresa Hastert, Bette Caan, Lihong Qi, Thomas Rohan

Abstract readMulticenter Study
In one paragraph

Article in Cancer prevention research (Philadelphia, Pa.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
2.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.

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  20. DNA Methylation inCancer management and research · 2020
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Rhonda ArthurDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York. rhonda.arthur@einstein.yu.edu.
Sylvia Wassertheil-SmollerDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York.
JoAnn E MansonDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Juhua LuoDepartment of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington, Indiana.
Linda SnetselaarDepartment of Epidemiology, School of Public Health, University of Iowa, Iowa City, Iowa.
Theresa HastertDepartment of Oncology, Wayne State University School of Medicine, Detroit, Michigan.ORCID 0000-0001-6251-6422
Bette CaanDivision of Research, Kaiser Permanente, Oakland, California.
Lihong QiDepartment of Public Health Science, School of Medicine, UC Davis, Davis, California.
Thomas RohanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York.
Albert Einstein College of Medicine · USBrigham and Women's Hospital · USDepartment of Public Health · USIndiana University Bloomington · USKaiser Permanente · USUniversity of Iowa · USWayne State University · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Jon C.D. Houtman · 2000 to 2026
$70.0M
NCI NIH HHS P30 CA086862
6 · The paper itself

Abstract

Although several modifiable risk factors have been independently associated with risk of breast cancer, few studies have investigated their joint association with breast cancer risk. Using a healthy lifestyle index (HLI) score, we assessed the association of a combination of selected modifiable risk factors (diet, alcohol, physical activity, BMI, and smoking) with risk of invasive breast cancer in the Women's Health Initiative (WHI). This study comprised 131,833 postmenopausal women, of whom 8,168 had breast cancer, who were enrolled in the WHI Observational Study or the WHI clinical trials. Cox proportional hazards regression was used to estimate the HRs and 95% confidence intervals (CI) for the association of the score with the risk of developing breast cancer overall and according to specific breast cancer clinicopathologic characteristics. There was a 4% reduction in the risk of breast cancer per unit increase in the HLI score. Compared with those with an HLI score in the lowest quintile level, those in the highest quintile level had 30%, 37%, and 30% lower risk for overall, ER

Indexed as

DietExerciseLife StyleWomen's HealthAgedBody Mass IndexBreast NeoplasmsFemaleFollow-Up StudiesHumansIncidenceMiddle AgedPostmenopausePrognosisProspective StudiesRisk Factors

Identifiers

PMID29483073
PMCPMC6866659
OpenAlexW2791728944

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.