ArticleAnnals of epidemiology2018
Why do studies show different associations between intrauterine exposure to maternal smoking and age at menarche?
Article in Annals of epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- The association between age at menarche and subsequent risk of chronic pain.Frontiers in global women's health · 2026Review
- Impact of Chemicals on the Age of Menarche: A Literature Review.Children (Basel, Switzerland) · 2023Review
- Exposure to polycyclic aromatic hydrocarbons during pregnancy and breast tissue composition in adolescent daughters and their mothers: a prospective cohort study.Breast cancer research : BCR · 2022Article
- Could maternal thyroid function during pregnancy affect daughters' age at menarche through child growth? A mediation analysis.Reproductive toxicology (Elmsford, N.Y.) · 2022Article
- Associations of prenatal exposure to polycyclic aromatic hydrocarbons with pubertal timing and body composition in adolescent girls: Implications for breast cancer risk.Environmental research · 2021Article
- Recalled maternal lifestyle behaviors associated with anti-müllerian hormone of adult female offspring.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
- Maternal pre-pregnancy body mass index, smoking in pregnancy, and alcohol intake in pregnancy in relation to pubertal timing in the children.BMC pediatrics · 2019Article
- Maternal Smoking During Pregnancy and Timing of Puberty in Sons and Daughters: A Population-Based Cohort Study.American journal of epidemiology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeStudies suggests that intrauterine exposure to maternal smoking both accelerates or delays age at menarche. We hypothesize that these opposing findings relate to different infant and childhood growth patterns across cohorts.
methodsUsing data from an adult follow-up study of the Child Health and Development Studies and the National Collaborative Perinatal Project, we examined, using generalized estimating linear regression models, whether intrauterine exposure to maternal smoking was associated with age at menarche in 1090 daughters before and after accounting for growth in weight.
resultsCompared to the nonexposed, intrauterine exposure to maternal smoking was associated with a 4-month acceleration in menarche in the National Collaborative Perinatal Project (β = -0.35 years; 95% confidence interval [CI]: -0.63, -0.08), but a 6-month delay in menarche in the Child Health and Development Studies (β = 0.48 years; 95% CI: 0.13, 0.83), despite having a similar reduction in birth weight in both cohorts (∼300 g). The results were more consistent across cohorts when we stratified by postnatal growth patterns. For example, in those with rapid weight gain (increasing two growth references from 0 to 4 years), intrauterine exposure to maternal smoking was related to a 7-month acceleration in menarche (β = -0.56 years; 95% CI: -0.95, -0.17).
conclusionsThese findings suggest that the association of intrauterine exposure to maternal smoking on age at menarche depends on postnatal growth patterns.
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