ReviewCancer imaging : the official publication of the International Cancer Imaging Society2018
Primary carcinosarcoma of the liver: imaging features and clinical findings in six cases and a review of the literature.
Review in Cancer imaging : the official publication of the International Cancer Imaging Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Clinical and imaging comparison of primary liver carcinosarcoma and sarcomatoid carcinoma.Abdominal radiology (New York) · 2026Article
- Hepatic carcinosarcoma: a rare and aggressive case with unusual molecular signature!Frontiers in oncology · 2026Article
- Case Report: Primary hepatic carcinosarcoma with ectopic β-hCG secretion and a paraneoplastic leukemoid reaction mimicking gynecologic and hematologic disease.Frontiers in oncology · 2026Article
- Hepatic carcinosarcoma with predominant sarcomatous component mimicking intrahepatic cholangiocarcinoma: a case report and literature review.Frontiers in medicine · 2026Article
- Management strategies for primary lung carcinosarcoma: a case study and comprehensive literature review.Journal of cancer research and clinical oncology · 2025Review
- Effect of trans-theoretical model-based nursing intervention on emotion and fear in post-liver cancer surgery patients.American journal of translational research · 2024Article
- A case report of comprehensive treatment for primary intraspinal carcinosarcoma.Frontiers in oncology · 2024Article
- Primary hepatic carcinosarcoma: a case report with insights from retrospective analysis of clinical characteristics and prognostic factors.Frontiers in medicine · 2024Article
- Imaging Findings of Hepatic Ewing's Sarcoma on Computed Tomography and Gadobenate Dimeglumine-enhanced Magnetic Resonance Imaging: A Case Report and Literature Review.Journal of clinical and translational hepatology · 2022Article
- SMARCA4-deficient rectal carcinoma with a sarcomatoid component: a case report.Clinical journal of gastroenterology · 2022Article
- Rare primary hepatic carcinosarcoma composed of hepatocellular carcinoma, cholangiocarcinoma, and sarcoma: a case report.The Journal of international medical research · 2021Article
- Case Report: Review of CT Findings and Histopathological Characteristics of Primary Liver Carcinosarcoma.Frontiers in genetics · 2021Article
- Primary hepatic malignant vascular tumors: a follow-up study of imaging characteristics and clinicopathological features.Cancer imaging : the official publication of the International Cancer Imaging Society · 2020Article
- The Clinicopathological and Imaging Characteristics of Primary Hepatic Carcinosarcoma and a Review of the Literature.Journal of hepatocellular carcinoma · 2020Article
- Imaging and clinical features of primary hepatic sarcomatous carcinoma.Cancer imaging : the official publication of the International Cancer Imaging Society · 2018Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCarcinosarcoma of the liver is a very rare tumor composed of a mixture of carcinomatous and sarcomatous elements. Less than 25 adequately documented cases have been reported, with inadequate description of imaging features. In order to improve the awareness of this rare tumor, this study aimed to analyze the clinicopathologic and imaging features of six cases of hepatic carcinosarcoma (HCS) confirmed by surgical pathologic evaluation.
methodsWe retrospectively studied the clinicopathologic and imaging features of six cases of HCS (matching the World Health Organization definition) and discussed the differential diagnosis on the basis of imaging findings. The patients, including five men and one woman, were 38 to 69 years of age. Five patients underwent CT scans, one underwent MRI scans.
resultsWhile 3 patients were positive for hepatitis-B surface antigen, 2 had cirrhosis. The largest tumor diameter ranged from 5.0 to 21.0 cm. Satellite nodules, venous thrombi, and organ invasion (gastric wall, gallbladder, and right adrenal gland) were identified. Pathologically, the carcinomatous components corresponded to hepatocellular carcinoma in three cases, cholangiocellular carcinoma in one case, and adenocarcinoma in two cases. The sarcomatous components exhibited complex features, with undifferentiated spindle cells in five cases and a leiomyosarcoma in one. All tumors showed heterogeneous density/intensity with extensive cystic change and necrosis; spot calcification was observed in one case. Capsule was not identified. While four tumors showed heterogeneous hypervascular enhancement, two showed hypovascular enhancement. All patients underwent surgical resection. The follow-up period ranged from 2 to 18 months. Four patients died from recurrence and metastasis.
conclusionsThe clinical and imaging features of HCS are heterogeneous. Due to the heterogenous nature and very low morbidity of HCS, combination of careful analysis of imaging findings and clinical features might be useful for a more accurate diagnosis of HCS.
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