Evidence map›Paper›PMID 29482591›Full record

ArticleJournal of translational medicine2018

Clinical significance of circulating microRNAs as markers in detecting and predicting congenital heart defects in children.

Yong Song, Hilda Higgins, Jing Guo, Katrina Harrison, En Nee Schultz, Belinda J Hales, Eric K Moses, Jack Goldblatt, Nicholas Pachter, Guicheng Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Role of miRNA in Cardiovascular Diseases in Children-Systematic Review.International journal of molecular sciences · 2024
    Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Epigenetic Mechanisms in Heart Diseases.Reviews in cardiovascular medicine · 2025
    Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. miRNAs in Heart Development and Disease.International journal of molecular sciences · 2024
    Review
  12. Article
  13. Posttranscriptional Regulation by Proteins and Noncoding RNAs.Advances in experimental medicine and biology · 2024
    Article
  14. Review
  15. Article
  16. Epigenetics in Congenital Heart Disease.Journal of the American Heart Association · 2022
    Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yong SongSchool of Public Health, Curtin University of Technology, Kent St, Bentley, WA, 6102, Australia.ORCID 0000-0002-8178-5641
Hilda HigginsCentre for Genetic Origins of Health and Disease, The University of Western Australia and Curtin University, 35 Stirling Highway, Crawley, WA, 6009, Australia.
Jing GuoSchool of Public Health, Curtin University of Technology, Kent St, Bentley, WA, 6102, Australia.
Katrina HarrisonGenetic Services & Familial Cancer Program of WA, King Edward Memorial Hospital for Women, Subiaco, WA, 6008, Australia.
En Nee SchultzSchool of Paediatrics and Child Health, The University of Western Australia, 35 Stirling Highway, Crawley, WA, 6009, Australia.
Belinda J HalesTelethon Kids Institute, The University of Western Australia, 35 Stirling Highway, Crawley, WA, 6009, Australia.
Eric K MosesCentre for Genetic Origins of Health and Disease, The University of Western Australia and Curtin University, 35 Stirling Highway, Crawley, WA, 6009, Australia.
Jack GoldblattGenetic Services & Familial Cancer Program of WA, King Edward Memorial Hospital for Women, Subiaco, WA, 6008, Australia.
Nicholas PachterGenetic Services & Familial Cancer Program of WA, King Edward Memorial Hospital for Women, Subiaco, WA, 6008, Australia.
Guicheng ZhangSchool of Public Health, Curtin University of Technology, Kent St, Bentley, WA, 6102, Australia. brad.zhang@curtin.edu.au.
The University of Western Australia · AUThe Kids Research Institute Australia · AUKing Edward Memorial Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCirculating microRNAs (miRNAs) are emerging as novel biomarkers for detecting cardiovascular diseases. In this study, we aimed to investigate the usefulness of miRNAs as biomarkers in diagnosing and predicting children with congenital heart defects (CHD), particularly in the context of multiple subtypes of CHD.

methodsWe recruited 26 families, each having a child with CHD and parents who do not have any cardiovascular disorder. 27 families unaffected by cardiovascular disease were also included as controls. Firstly, we screened 84 circulating miRNAs relating to cardiovascular development in 6 children with atrial septal defects (ASD) and 5 healthy children. We validated the selected miRNAs with differential expression in a larger sample size (n = 27 for controls, n = 26 for cases), and evaluated their signal in different types of septal defects. Finally, we examined the identified miRNAs signatures in the parent population and assessed their diagnostic values for predicting CHD.

resultsThe three miRNAs hsa-let-7a, hsa-let-7b and hsa-miR-486 were significantly upregulated in children with ASD. A further validation study showed that overexpression of hsa-let-7a and hsa-let-7b was specifically present in ASD children, but not in children with other subtypes of septal defects. A similar expression profile of hsa-let-7a and hsa-let-7b was discovered in mothers of ASD children. Receiver-operating characteristic curve analyses indicated that hsa-let-7a and hsa-let-7b had significant diagnostic values for detecting ASD and in maternal samples predicting the occurrence of ASD in offspring.

conclusionsCirculating miRNAs are important markers not only for diagnosing CHD, but also for predicting CHD risk in offspring. The distinct miRNA signatures are likely to present in various subtypes of CHD, and the phenotypic heterogeneity of CHD should be considered to develop such miRNA-based assays.

Indexed as

BiomarkersChildCirculating MicroRNAFemaleGene Expression RegulationHeart Defects, CongenitalHumansMalePrognosisReproducibility of ResultsROC CurveBiomarkersCirculating MicroRNACongenital heart defectsDiagnostic biomarkersMicroRNA

Identifiers

PMID29482591
PMCPMC5828434
OpenAlexW2795726009

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.