Evidence map›Paper›PMID 29482392›Full record

ArticleInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group2018

Laser immunotherapy for cutaneous squamous cell carcinoma with optimal thermal effects to enhance tumour immunogenicity.

Min Luo, Lei Shi, Fuhe Zhang, Feifan Zhou, Linglin Zhang, Bo Wang, Peiru Wang, Yunfeng Zhang, Haiyan Zhang, Degang Yang and 3 more

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. The Immunogenetic Aspects of Photodynamic Therapy.Advances in experimental medicine and biology · 2022
    Article
  7. Article
  8. Article
  9. Review
  10. Laser adjuvant for vaccination.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Min Luoa Institute of Photomedicine, Shanghai Skin Disease Hospital , Tongji University School of Medicine , Shanghai , PR China.
Lei Shia Institute of Photomedicine, Shanghai Skin Disease Hospital , Tongji University School of Medicine , Shanghai , PR China.
Fuhe Zhanga Institute of Photomedicine, Shanghai Skin Disease Hospital , Tongji University School of Medicine , Shanghai , PR China.
Feifan Zhoub Biophotonics Research Laboratory , Center for Interdisciplinary Biomedical Education and Research University of Central Oklahoma , Edmond , OK , USA.
Linglin Zhanga Institute of Photomedicine, Shanghai Skin Disease Hospital , Tongji University School of Medicine , Shanghai , PR China.
Bo Wanga Institute of Photomedicine, Shanghai Skin Disease Hospital , Tongji University School of Medicine , Shanghai , PR China.
Peiru Wanga Institute of Photomedicine, Shanghai Skin Disease Hospital , Tongji University School of Medicine , Shanghai , PR China.
Yunfeng Zhanga Institute of Photomedicine, Shanghai Skin Disease Hospital , Tongji University School of Medicine , Shanghai , PR China.
Haiyan Zhanga Institute of Photomedicine, Shanghai Skin Disease Hospital , Tongji University School of Medicine , Shanghai , PR China.
Degang Yanga Institute of Photomedicine, Shanghai Skin Disease Hospital , Tongji University School of Medicine , Shanghai , PR China.
Guolong Zhanga Institute of Photomedicine, Shanghai Skin Disease Hospital , Tongji University School of Medicine , Shanghai , PR China.
Wei R Chena Institute of Photomedicine, Shanghai Skin Disease Hospital , Tongji University School of Medicine , Shanghai , PR China.ORCID 0000-0002-7133-5794
Xiuli Wanga Institute of Photomedicine, Shanghai Skin Disease Hospital , Tongji University School of Medicine , Shanghai , PR China.
Tongji University · CNUniversity of Central Oklahoma · US

Funding

Mechanistic study on synergistic photo-immunological effects of laser immunotherapy for metastatic cancersR01CA205348 · NCI · UNIVERSITY OF OKLAHOMA · PI CHEN, WEI R. · 2017 to 2021
$1.5M
A Novel Multifunctional Bionanoprobe-Based Phototherapy for Metastatic CancersR21EB015509 · NIBIB · UNIVERSITY OF CENTRAL OKLAHOMA · PI CHEN, WEI R. · 2013 to 2014
$350k
NCI NIH HHS R01 CA205348NIBIB NIH HHS R21 EB015509
6 · The paper itself

Abstract

backgroundLaser immunotherapy is a new anti-cancer therapy combining photothermal therapy and immunostimulation. It can eliminate the tumours by damaging tumour cells directly and promoting the release of damage-associated molecular patterns (DAMPs) to enhance tumour immunogenicity. The aim of this study was to investigate the thermal effects of laser immunotherapy and to evaluate the effectiveness and safety of laser immunotherapy for cutaneous squamous cell carcinoma (cSCC).

methodsThe cell viability and the DAMPs productions of heat-treated cSCC A431 cells in different temperatures were investigated. Laser immunotherapy with the optimal thermal effect for DAMPs production was performed on SKH-1 mice bearing ultraviolet-induced cSCC and a patient suffering from a large refractory cSCC.

resultsThe temperature in the range of 45-50 °C killing half of A431 cells had an optimal thermal effect for the productions of DAMPs. The thermal effect could be further enhanced by local application of imiquimod, an immunoadjuvant. Laser immunotherapy eliminated most tumours and improved the survival rate of the ultraviolet-induced cSCC-bearing SKH-1 mice (p < 0.05). The patient with cSCC treated by laser immunotherapy experienced a significant tumour reduction after laser immunotherapy increased the amounts of infiltrating lymphocytes in the tumour. No obviously adverse effect was observed in the mice experiment or in the clinical application.

conclusionsOur results strongly indicate that laser immunotherapy with optimal thermal effects is an effective and safe treatment modality for cSCC.

Indexed as

ImmunotherapyLaser TherapyPhototherapyAdjuvants, ImmunologicAnimalsCarcinoma, Squamous CellCell Line, TumorCombined Modality TherapyFemaleHMGB1 ProteinHSP70 Heat-Shock ProteinsHSP90 Heat-Shock ProteinsHumansImiquimodMiceMiddle AgedAdjuvants, ImmunologicHMGB1 ProteinHSP70 Heat-Shock ProteinsHSP90 Heat-Shock ProteinsImiquimodCutaneous squamous cell carcinoma (cSCC)damage-associated molecular patterns (DAMPs)imiquimodlaser immunotherapyphotothermal

Identifiers

PMID29482392
PMCPMC6136962
OpenAlexW2792896584

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.