ArticleJournal of medicinal chemistry2018
Design and Synthesis of Novel Deuterated Ligands Functionally Selective for the γ-Aminobutyric Acid Type A Receptor (GABA
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Article in Journal of medicinal chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
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Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
- Behavioral Domain-Specific Effects of Positive Modulation of α5 and α6 GABAPharmacology research & perspectives · 2026Article
- Intravenous Nanoemulsions Loaded with Phospholipid Complex of a Novel Pyrazoloquinolinone Ligand for Enhanced Brain Delivery.Pharmaceutics · 2025Article
- Complex Hippocampal Response to Thermal Skin Injury and Protocols with Hyperbaric Oxygen Therapy andInternational journal of molecular sciences · 2024Article
- The deuterated pyrazoloquinolinone targeting α6 subunit-containing GABAFrontiers in pharmacology · 2024Article
- Why Can Modulation of α6-Containing GABAArchives of pharmacology and therapeutics · 2024Article
- Structural Optimization and Anticancer Activity of Polo-like Kinase 1 (Plk1) Polo-Box Domain (PBD) Inhibitors and Their Prodrugs.ACS pharmacology & translational science · 2023Article
- Cerebellar α6GABANeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
- High amount of lecithin facilitates oral delivery of a poorly soluble pyrazoloquinolinone ligand formulated in lipid nanoparticles: Physicochemical, structural and pharmacokinetic performances.International journal of pharmaceutics · 2023Article
- Deuterated Drugs and Biomarkers in the COVID-19 Pandemic.ACS omega · 2022Review
- Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach.Pharmaceutics · 2021Article
- The α6 GABABiomolecules · 2021Article
- α6GABANeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Article
- An open source chemical structure curation pipeline using RDKit.Journal of cheminformatics · 2020Article
- Nanocrystal dispersion of DK-I-56-1, a poorly soluble pyrazoloquinolinone positive modulator of α6 GABAA receptors: Formulation approach toward improved in vivo performance.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2020Article
- Structure-Guided Computational Methods Predict Multiple Distinct Binding Modes for Pyrazoloquinolinones in GABAFrontiers in neuroscience · 2020Article
- Effects of the α2/α3-subtype-selective GABAA receptor positive allosteric modulator KRM-II-81 on pain-depressed behavior in rats: comparison with ketorolac and diazepam.Behavioural pharmacology · 2019Article
- Trigeminal neuropathic pain development and maintenance in rats are suppressed by a positive modulator of α6 GABAEuropean journal of pain (London, England) · 2019Article
- Synthesis of New GABAInternational journal of molecular sciences · 2019Article
- The α6 subunit-containing GABANeuropharmacology · 2018Article
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 4 countries.
Daniel E KnutsonDepartment of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery , University of Wisconsin-Milwaukee , 3210 N. Cramer St. , Milwaukee , Wisconsin 53211 , United States.ORCID 0000-0002-8043-767X
Revathi KodaliDepartment of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery , University of Wisconsin-Milwaukee , 3210 N. Cramer St. , Milwaukee , Wisconsin 53211 , United States.
Branka DivovićDepartment of Pharmacology, Faculty of Pharmacy , University of Belgrade , Vojvode Stepe 450 , 11221 Belgrade , Serbia.
Marco TrevenDepartment of Molecular Neurosciences, Center for Brain Research , Medical University of Vienna , Spitalgasse 4 , A-1090 Vienna , Austria.
Michael R StephenDepartment of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery , University of Wisconsin-Milwaukee , 3210 N. Cramer St. , Milwaukee , Wisconsin 53211 , United States.ORCID 0000-0003-0027-6560
Nicolas M ZahnDepartment of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery , University of Wisconsin-Milwaukee , 3210 N. Cramer St. , Milwaukee , Wisconsin 53211 , United States.
Vladimir DobričićDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy , University of Belgrade , Vojvode Stepe 450 , 11221 Belgrade , Serbia.
Alec T HuberDepartment of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery , University of Wisconsin-Milwaukee , 3210 N. Cramer St. , Milwaukee , Wisconsin 53211 , United States.
Matheus A MeirellesDepartment of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery , University of Wisconsin-Milwaukee , 3210 N. Cramer St. , Milwaukee , Wisconsin 53211 , United States.
Ranjit S VermaDepartment of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery , University of Wisconsin-Milwaukee , 3210 N. Cramer St. , Milwaukee , Wisconsin 53211 , United States.
Laurin WimmerTU Wien-Institute of Applied Synthetic Chemistry , Getreidemarkt 9/163 , A-1060 Vienna , Austria.
Christopher WitzigmannDepartment of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery , University of Wisconsin-Milwaukee , 3210 N. Cramer St. , Milwaukee , Wisconsin 53211 , United States.
Leggy A ArnoldDepartment of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery , University of Wisconsin-Milwaukee , 3210 N. Cramer St. , Milwaukee , Wisconsin 53211 , United States.ORCID 0000-0003-1411-1572
Lih-Chu ChiouGraduate Institute of Acupuncture Science , China Medical University , Taichung 40402 , Taiwan.ORCID 0000-0001-5356-940X
Margot ErnstDepartment of Molecular Neurosciences, Center for Brain Research , Medical University of Vienna , Spitalgasse 4 , A-1090 Vienna , Austria.
Marko D MihovilovicTU Wien-Institute of Applied Synthetic Chemistry , Getreidemarkt 9/163 , A-1060 Vienna , Austria.
Miroslav M SavićDepartment of Pharmacology, Faculty of Pharmacy , University of Belgrade , Vojvode Stepe 450 , 11221 Belgrade , Serbia.
Werner SieghartDepartment of Molecular Neurosciences, Center for Brain Research , Medical University of Vienna , Spitalgasse 4 , A-1090 Vienna , Austria.
James M CookDepartment of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery , University of Wisconsin-Milwaukee , 3210 N. Cramer St. , Milwaukee , Wisconsin 53211 , United States.ORCID 0000-0001-5512-3022
University of Wisconsin–Milwaukee · USMedical University of Vienna · ATUniversity of Belgrade · RSTU Wien · ATChina Medical University · TW
Funding
Design of New Therapeutic Agents to Treat SchizophreniaR01MH096463 · NIMH · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2013 to 2017
$1.9MSynthesis of Alpha2/Alpha3 GABA Agonists to Treat Neuropathic PainR01NS076517 · NINDS · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2012 to 2015
$1.3MSmall molecule inhibitors of the vitamin D receptor-coactivator interactionR03DA031090 · NIDA · UNIVERSITY OF WISCONSIN MILWAUKEE · PI ARNOLD, ALEXANDER · 2010 to 2011
$73kAustrian Science Fund FWF I 2306Austrian Science Fund FWF W 1232NIDA NIH HHS R03 DA031090NIMH NIH HHS R01 MH096463NINDS NIH HHS R01 NS076517
Abstract
Recent reports indicate that α6β2/3γ2 GABA
Indexed as
AnimalsAnti-Anxiety AgentsBehavior, AnimalBiological AvailabilityDeuteriumDrug DesignFemaleGABA AntagonistsHEK293 CellsHumansHypnotics and SedativesMaleMaze LearningMiceMice, Inbred C57BLMicrosomes, LiverAnti-Anxiety AgentsDeuteriumGABA AntagonistsGABRA6 protein, humanGabra6 protein, mouseHypnotics and SedativesReceptors, GABA-A
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.