Evidence map›Paper›PMID 29481703›Full record

ArticleMedical physics2018

Quality assurance tool for organ at risk delineation in radiation therapy using a parametric statistical approach.

Cheukkai B Hui, Hamidreza Nourzadeh, William T Watkins, Daniel M Trifiletti, Clayton E Alonso, Sunil W Dutta, Jeffrey V Siebers

Abstract read
In one paragraph

Article in Medical physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cheukkai B HuiDepartment of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Hamidreza NourzadehDepartment of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, VA, USA.
William T WatkinsDepartment of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Daniel M TrifilettiDepartment of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Clayton E AlonsoDepartment of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Sunil W DuttaDepartment of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Jeffrey V SiebersDepartment of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, VA, USA.

Funding

Comprehensive analysis and mitigation of the clinical effects of delineation and geometric uncertainties in conformal radiation therapyR01CA222216 · NCI · UNIVERSITY OF VIRGINIA · PI SIEBERS, JEFFREY VINCENT · 2018 to 2023
$1.6M
NCI NIH HHS R01 CA222216
6 · The paper itself

Abstract

purposeTo develop a quality assurance (QA) tool that identifies inaccurate organ at risk (OAR) delineations.

methodsThe QA tool computed volumetric features from prior OAR delineation data from 73 thoracic patients to construct a reference database. All volumetric features of the OAR delineation are computed in three-dimensional space. Volumetric features of a new OAR are compared with respect to those in the reference database to discern delineation outliers. A multicriteria outlier detection system warns users of specific delineation outliers based on combinations of deviant features. Fifteen independent experimental sets including automatic, propagated, and clinically approved manual delineation sets were used for verification. The verification OARs included manipulations to mimic common errors. Three experts reviewed the experimental sets to identify and classify errors, first without; and then 1 week after with the QA tool.

resultsIn the cohort of manual delineations with manual manipulations, the QA tool detected 94% of the mimicked errors. Overall, it detected 37% of the minor and 85% of the major errors. The QA tool improved reviewer error detection sensitivity from 61% to 68% for minor errors (P = 0.17), and from 78% to 87% for major errors (P = 0.02).

conclusionsThe QA tool assists users to detect potential delineation errors. QA tool integration into clinical procedures may reduce the frequency of inaccurate OAR delineation, and potentially improve safety and quality of radiation treatment planning.

Indexed as

Statistics as TopicOrgans at RiskQuality Assurance, Health CareRadiotherapyRisk Assessmentdelineationnormal tissueOARquality assurancesegmentation

Identifiers

PMID29481703
PMCPMC8220860

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.