SynthesisPlastic and reconstructive surgery2018
A Systematic Review and Meta-Analysis on the Strength and Consistency of the Associations between Dupuytren Disease and Diabetes Mellitus, Liver Disease, and Epilepsy.
Synthesis in Plastic and reconstructive surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Collagenase clostridium histolyticum injection versus limited fasciectomy for the treatment of Dupuytren's disease: a systematic review and meta-analysis of comparative studies.Archives of orthopaedic and trauma surgery · 2024Pooled it
- Fibroproliferative disorders and diabetes: Understanding the pathophysiologic relationship between Peyronie's disease, Dupuytren disease and diabetes.Endocrinology, diabetes & metabolism · 2021Pooled it
- The worldwide prevalence of the Dupuytren disease: a comprehensive systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2020Pooled it
- Imaging for Dupuytren disease: a systematic review of the literature.BMC musculoskeletal disorders · 2019Pooled it
- New-Onset Dupuytren After Surgical Treatment of Carpal Tunnel and Trigger Finger.Hand (New York, N.Y.) · 2026Article
- Treatment of Dupuytren Contracture Recurrence After Surgery With Collagenase Clostridium Histolyticum: A Retrospective Multicenter Series.Journal of hand surgery global online · 2026Article
- Associations of Glycemic Control and Diabetes Duration With Dupuytren Disease in Men and Women With Type 1 and 2 Diabetes.Plastic and reconstructive surgery. Global open · 2026Article
- Associations of Demographic, Lifestyle, and Clinical Factors With the Presence of Dupuytren Disease: Results from the Lifelines Cohort Study.Journal of hand surgery global online · 2025Article
- Early postinterventional clinical implications of Collagenase Clostridium Histolyticum injection versus limited fasciectomy for Dupuytren's disease.Journal of hand and microsurgery · 2025Article
- Surgical Trigger Finger Release Is Associated With New-Onset Dupuytren Contracture in the Short-Term Postoperative Period: A Matched Analysis.Hand (New York, N.Y.) · 2023Article
- The prevalence of Dupuytren's disease in patients with diabetes mellitus.Communications medicine · 2023Article
- Initial Treatment Choice Affects Cost-Effectiveness and Reintervention Rates for Dupuytren Contracture: A National Census Among Veterans Affairs Patients.Hand (New York, N.Y.) · 2023Article
- Analysis of a National Database Investigating Development of Trigger Finger after Treatment of Dupuytren Disease.Plastic and reconstructive surgery. Global open · 2023Article
- Exploring the causal role of the immune response to varicella-zoster virus on multiple traits: a phenome-wide Mendelian randomization study.BMC medicine · 2023Article
- Exploring the potential relationship between frozen shoulder and Dupuytren's disease through bioinformatics analysis and machine learning.Frontiers in immunology · 2023Article
- Quantification of joint mobility limitation in adult type 1 diabetes.Frontiers in endocrinology · 2023Article
- Does hand stiffness reflect internal organ fibrosis in diabetes mellitus?Frontiers in clinical diabetes and healthcare · 2023Article
- Possible Association with Barbiturates.Deutsches Arzteblatt international · 2022Article
- Risk Factors for Dupuytren's Contracture: A Case-Control Study.Computational intelligence and neuroscience · 2022Article
- Diabetic hand: prevalence and incidence of diabetic hand problems using data from 1.1 million inhabitants in southern Sweden.BMJ open diabetes research & care · 2022Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of diabetes mellitus, liver disease, and epilepsy as risk factors for Dupuytren disease remains unclear. In this systematic review and meta-analysis, the strength and consistency of these associations were examined.
methodsThe MEDLINE, EMBASE, and Web of Science databases were searched for articles reporting an association between Dupuytren disease and diabetes mellitus, liver disease, and epilepsy published before September 26, 2016. The frequencies of Dupuytren disease and diabetes mellitus, liver disease, and epilepsy were extracted, as was information on potential confounders. Generalized linear mixed models were applied to estimate pooled odds ratios, adjusted for confounders. Heterogeneity between studies was quantified using an intraclass correlation coefficient and was accounted for by a random effect for study.
resultsOne thousand two hundred sixty unique studies were identified, of which 32 were used in the meta-analyses. An association between Dupuytren disease and diabetes mellitus was observed (OR, 3.06; 95 percent CI, 2.69 to 3.48, adjusted for age), which was stronger for type 1 diabetes mellitus than for type 2 diabetes mellitus but was not statistically significant (p = 0.24). An association between Dupuytren disease and liver disease was observed (OR, 2.92; 95 percent CI, 2.08 to 4.12, adjusted for sex). Dupuytren disease and epilepsy were associated, yielding an OR of 2.80 (95 percent CI, 2.49 to 3.15). Heterogeneity between studies was moderate to low.
conclusionsThese findings demonstrate an association between Dupuytren disease and diabetes mellitus, liver disease, and epilepsy. Prospective, longitudinal studies are needed to elucidate the pathways causing these associations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.