Evidence map›Paper›PMID 29481322›Full record

ArticleeLife2018

CATaDa reveals global remodelling of chromatin accessibility during stem cell differentiation in vivo.

Gabriel N Aughey, Alicia Estacio Gomez, Jamie Thomson, Hang Yin, Tony D Southall

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 95 citations in OpenAlex.

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  20. STAR protocols · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Gabriel N AugheyDepartment of Life Sciences, Imperial College London, London, United Kingdom.ORCID 0000-0001-5610-9345
Alicia Estacio GomezDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Jamie ThomsonDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Hang YinDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Tony D SouthallDepartment of Life Sciences, Imperial College London, London, United Kingdom.ORCID 0000-0002-8645-4198
Imperial College London · GB

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
NIH HHS P40 OD018537Wellcome TrustWellcome Trust Wellcome Trust Investigator Grant 104567
6 · The paper itself

Abstract

During development eukaryotic gene expression is coordinated by dynamic changes in chromatin structure. Measurements of accessible chromatin are used extensively to identify genomic regulatory elements. Whilst chromatin landscapes of pluripotent stem cells are well characterised, chromatin accessibility changes in the development of somatic lineages are not well defined. Here we show that cell-specific chromatin accessibility data can be produced via ectopic expression of

Indexed as

Cell DifferentiationEpigenesis, GeneticAnimalsChromatinDrosophilaEscherichia coli ProteinsGene Expression Regulation, DevelopmentalPluripotent Stem CellsSite-Specific DNA-Methyltransferase (Adenine-Specific)Staining and LabelingChromatindam protein, E coliEscherichia coli ProteinsSite-Specific DNA-Methyltransferase (Adenine-Specific)chromatin accessibilitychromosomesdevelopmental biologydifferentiationD. melanogastergenesneural developmentstem cells

Identifiers

PMID29481322
PMCPMC5826290
OpenAlexW2756282286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.